Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Semin Thromb Hemost. 2018 Jul;44(5):445-452. doi: 10.1055/s-0037-1606190. Epub 2017 Sep 12.
Lupus anticoagulant (LA) represents the most enigmatic antibody population in patients with antiphospholipid syndrome and represents a paradox that is still unsolved. This class of antiphospholipid antibody causes a phospholipid-dependent prolongation of the clotting time but is associated with an increased risk of thrombosis and pregnancy morbidity. In this review, we will provide an overview of the different antibodies that have been associated with LA activity, their importance based on clinical studies, and address the question why this prolongation of the clotting time is associated with thrombosis rather than a bleeding tendency.
狼疮抗凝物 (LA) 是抗磷脂综合征患者中最神秘的抗体群体，代表着一个尚未解决的悖论。这类抗磷脂抗体可导致磷脂依赖性凝血时间延长，但与血栓形成和妊娠并发症风险增加相关。在这篇综述中，我们将概述与 LA 活性相关的不同抗体，根据临床研究评估其重要性，并探讨为什么这种凝血时间延长与血栓形成相关，而不是出血倾向。
