Córdoba-Fernández Antonio, Marmol-García Francisco, Córdoba-Jiménez Victoria Eugenia
Departamento de Podología, Universidad de Sevilla, Avicena Street s/n, 41009 Sevilla, Spain.
Área Clínica de Podología, Universidad de Sevilla, Avicena Street s/n, 41009 Sevilla, Spain.
Life (Basel). 2023 Apr 13;13(4):1009. doi: 10.3390/life13041009.
This study highlights the importance of having a high clinical suspicion of hypercoagulopathy such as antiphospholipid syndrome (APS) in podiatric patients with normal foot pulses and normal standard coagulation tests. APS is an autoimmune disease that is characterized by inflammatory thrombosis in the arteries and veins and obstetric complications such as pregnancy loss. APS usually affects vessels of the lower extremities. We report herein the case of a 46-year-old woman with previous episodes of pre-eclampsia who suffered from partial ischemic necrosis of the hallux of the left foot. After several ischemic episodes of the hallux, with increased risk of toe amputation, the patient was finally diagnosed with APS and treated with specific anticoagulant medication. The patient's symptoms subsided, and toe amputation was prevented. Early accurate diagnosis and appropriate clinical management are critical to providing optimal outcomes and reducing the risk of amputation.
本研究强调了对于足部脉搏正常且标准凝血检查正常的足病患者，高度怀疑存在高凝状态（如抗磷脂综合征（APS））的重要性。APS是一种自身免疫性疾病，其特征为动静脉炎症性血栓形成以及诸如流产等产科并发症。APS通常影响下肢血管。我们在此报告一例46岁女性病例，该患者既往有子痫前期发作史，现患有左足足趾部分缺血性坏死。在足趾经历数次缺血发作且截肢风险增加后，该患者最终被诊断为APS，并接受了特异性抗凝药物治疗。患者症状缓解，避免了足趾截肢。早期准确诊断和恰当的临床管理对于实现最佳治疗效果及降低截肢风险至关重要。
