Kabataş Emrah Utku, Dinlen Nurdan Fettah, Zenciroğlu Ayşegül, Dilli Dilek, Beken Serdar, Okumuş Nurullah
1 MD, Department of Ophtalmology, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Turkey.
2 MD, Department of Neonatology, Dr. Sami Ulus Maternity and Children Research and Training Hospital, Turkey.
Scott Med J. 2017 Nov;62(4):129-135. doi: 10.1177/0036933017701867. Epub 2017 Sep 13.
Aim To evaluate the relationship between serum 25-hydroxy vitamin D, 25 (OH) D, levels and retinopathy of prematurity. Methods and Results Serum 25 (OH) D levels were measured in 97 very low birth weight infants, prior to vitamin D supplementation. The development of retinopathy of prematurity and its treatment requirement were evaluated. At follow-up, retinopathy of prematurity developed in 71 (73.2%) infants. Serum 25 (OH) D levels were significantly lower in infants with retinopathy of prematurity than ones without retinopathy of prematurity ( P < 0.001). The infants who required treatment had lower 25 (OH) D levels compared with the infants who did not required treatment (7.1 ± 5.2 ng/ml vs. 11.9 ± 6.5 ng/ml; P = 0.003). Multivariate analysis showed that lower serum 25 (OH) D levels may be a risk factor for retinopathy of prematurity development [OR: 1.14, 95% CI (1.02-1.27), P = 0.02]. Conclusion Lower 25 (OH) D levels in the first days of life may be related to retinopathy of prematurity development and treatment requirement in premature infants.
目的 评估血清25-羟维生素D[25(OH)D]水平与早产儿视网膜病变之间的关系。方法与结果 在97例极低出生体重儿补充维生素D之前，检测其血清25(OH)D水平。评估早产儿视网膜病变的发生情况及其治疗需求。随访时，71例(73.2%)婴儿发生了早产儿视网膜病变。发生早产儿视网膜病变的婴儿血清25(OH)D水平显著低于未发生早产儿视网膜病变的婴儿(P<0.001)。需要治疗的婴儿25(OH)D水平低于不需要治疗的婴儿(7.1±5.2 ng/ml对11.9±6.5 ng/ml;P=0.003)。多因素分析显示，血清25(OH)D水平降低可能是早产儿视网膜病变发生的危险因素[比值比:1.14，95%可信区间(1.02 - 1.27)，P=0.02]。结论 出生后早期25(OH)D水平降低可能与早产儿视网膜病变的发生及治疗需求有关。
