Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute and Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute and Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Cytokine. 2019 Oct;122:154148. doi: 10.1016/j.cyto.2017.09.004. Epub 2017 Sep 11.
The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been implicated in several pathologic conditions, including infectious diseases, psychiatric disorders, malignancies, and autoimmune and chronic inflammatory diseases. Additionally, recent studies have linked the KP with atherosclerosis, suggesting that Trp metabolism could play an essential role in the maintenance of immune homeostasis in the vascular wall. This review summarizes experimental and clinical evidence of the interplay between cytokines and the KP and the potential role of the KP in cardiovascular diseases.
犬尿氨酸途径（KP）是色氨酸（Trp）代谢的主要代谢途径。吲哚胺 2,3-双加氧酶（IDO1）是该途径中负责第一步和限速步骤的酶，以及该途径中的其他酶，已被证明受到细胞因子的高度调节。因此，KP 与几种病理状况有关，包括传染病、精神疾病、恶性肿瘤以及自身免疫性和慢性炎症性疾病。此外，最近的研究将 KP 与动脉粥样硬化联系起来，表明 Trp 代谢可能在血管壁中维持免疫内稳态方面发挥重要作用。本综述总结了细胞因子与 KP 相互作用的实验和临床证据，以及 KP 在心血管疾病中的潜在作用。
