Amutha Periyasamy, Rajkumar Thangarajan
Department of Molecular Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
Indian J Med Paediatr Oncol. 2017 Apr-Jun;38(2):198-206. doi: 10.4103/ijmpo.ijmpo_3_17.
Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally, insulin is associated with metabolism, whereas Insulin like growth factors (IGFs) are involved in cell proliferation. Hence, Insulin-like growth factor binding proteins (IGFBPs) determines the bioavailability of IGFs in circulation. The interplay between these molecules such as insulin, IGFs, IGFBPs and insulin-like growth factor receptor 1 (IGF1R) may be crucial for ovarian cancer cell biology and cancer progression. However, the IGF1R inhibitors exhibiting potent activity on IGF/IGF1R also demonstrated activity against OC cells. The combination therapy of drugs may prove to be beneficial in clinical management of OC. This review describes both molecular and clinical associations between insulin and IGF1 signaling pathways in ovarian cancer. The data was collected using PubMed search engine with the following key words such as ovarian cancer, IGFs, IGFBP, IGF1Rs and ovarian cancer.
胰岛素和胰岛素样生长因子（IGFs）在包括卵巢癌（OC）在内的癌症发生和发展过程中发挥着重要作用。上皮性卵巢癌（EOC）是女性中最常见的OC类型，也是全球最致命的妇科恶性肿瘤。一般来说，胰岛素与代谢相关，而胰岛素样生长因子（IGFs）参与细胞增殖。因此，胰岛素样生长因子结合蛋白（IGFBPs）决定了循环中IGFs的生物利用度。胰岛素、IGFs、IGFBPs和胰岛素样生长因子受体1（IGF1R）等这些分子之间的相互作用可能对卵巢癌细胞生物学特性和癌症进展至关重要。然而，对IGF/IGF1R表现出强效活性的IGF1R抑制剂也显示出对OC细胞的活性。联合药物治疗可能被证明对OC的临床管理有益。本综述描述了卵巢癌中胰岛素和IGF1信号通路之间的分子和临床关联。使用PubMed搜索引擎，通过诸如卵巢癌、IGFs、IGFBP、IGF1R和卵巢癌等关键词收集数据。
