Institute for Neurorehabilitation Research, BDH-Clinic Hessisch Oldendorf, Hannover Medical School, Hannover, Germany.
Biomed Res Int. 2017;2017:4719279. doi: 10.1155/2017/4719279. Epub 2017 Aug 16.
Neurological and neurosurgical early rehabilitation (NNER) is a specialized treatment option for patients with severe neurological disorders. The present study investigated whether thyroid hormone levels on admission have an impact on the outcome of NNER patients.
The study included 500 NNER patients who were admitted to the BDH-Clinic Hessisch Oldendorf between 2009 and 2010. Data such as age, sex, diagnoses, comorbidities, Glasgow Coma Scale score, length of stay, and thyroid hormone levels (obtained as part of clinical routine care) were analyzed retrospectively. Improvement in the Early Rehabilitation Barthel Index (ERBI) at the end of the NNER treatment was defined as outcome parameter.
Most patients made functional progress during treatment, as reflected in significant enhancements of the ERBI. Approximately half of the patients were transferred to further rehabilitation treatment. Young age, early onset of NNER treatment, low functional impairment on admission, and, in particular, low total T3 levels were independently associated with a good outcome.
Age, severity of disease, and time between injury and admission are known to predict outcome. The present study confirms the influence of these general factors. In addition, an association between thyroid hormones and functional outcome was demonstrated for NNER patients.
神经和神经外科早期康复（NNER）是严重神经障碍患者的一种专业治疗选择。本研究调查了入院时的甲状腺激素水平是否对 NNER 患者的预后有影响。
本研究纳入了 2009 年至 2010 年期间在 BDH-Clinic Hessisch Oldendorf 就诊的 500 名 NNER 患者。回顾性分析了年龄、性别、诊断、合并症、格拉斯哥昏迷量表评分、住院时间和甲状腺激素水平（作为临床常规护理的一部分获得）等数据。NNER 治疗结束时早期康复巴氏指数（ERBI）的改善被定义为预后参数。
大多数患者在治疗过程中取得了功能进展，反映在 ERBI 显著提高。约一半的患者被转至进一步的康复治疗。年轻、NNER 治疗早期开始、入院时功能损伤程度低，特别是总 T3 水平低与良好的预后独立相关。
年龄、疾病严重程度和损伤与入院时间之间的关系已知可预测预后。本研究证实了这些一般因素的影响。此外，还证明了 NNER 患者的甲状腺激素与功能结果之间存在关联。
