Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London , Exhibition Road, London SW7 2AZ, U.K.
J Am Chem Soc. 2017 Oct 4;139(39):13592-13595. doi: 10.1021/jacs.7b06591. Epub 2017 Sep 13.
We report the thermodynamically controlled growth of solution-processable and free-standing nanosheets via peptide assembly in two dimensions. By taking advantage of self-sorting between peptide β-strands and hydrocarbon chains, we have demonstrated the formation of Janus 2D structures with single-layer thickness, which enable a predetermined surface heterofunctionalization. A controlled 2D-to-1D morphological transition was achieved by subtly adjusting the intermolecular forces. These nanosheets provide an ideal substrate for the engineering of guest components (e.g., proteins and nanoparticles), where enhanced enzyme activity was observed. We anticipate that sequence-specific programmed peptides will offer promise as design elements for 2D assemblies with face-selective functionalization.
我们报告了通过肽组装在二维空间中实现的热力学控制的溶液可加工和独立纳米片的生长。通过利用肽β-链和碳氢链之间的自分类，我们已经证明了具有单层厚度的单原子层厚度的 Janus 2D 结构的形成，这使得可以进行预定的表面杂化功能化。通过巧妙地调节分子间力，可以实现受控的 2D 到 1D 形态转变。这些纳米片为工程化的客体制备提供了理想的基底（例如，蛋白质和纳米颗粒），在其中观察到了增强的酶活性。我们预计，序列特异性编程肽将作为具有面选择性功能化的 2D 组装的设计元素提供前景。
