Brady M M, Mirakhur R K, Gibson F M
Department of Anaesthetics, Queen's University of Belfast, N. Ireland.
Br J Anaesth. 1987 Oct;59(10):1245-9. doi: 10.1093/bja/59.10.1245.
Dose-response curves have been constructed to determine the ED50 and ED95 (doses required to produce a 50% and a 95% block, respectively) following administration of a small "priming" dose of atracurium 50 micrograms kg-1, vecuronium 10 micrograms kg-1 or pancuronium 10 micrograms kg-1. The myoneural blockers were administered subsequently as a single bolus. The results were compared with previously published work on these drugs, in which no priming dose had been administered. The respective ED50 and ED95 values in the primed and control groups were 122 and 126 micrograms kg-1 and 208 and 226 micrograms kg-1, respectively, for atracurium; 26 and 23 micrograms kg-1 and 42 and 39 micrograms kg-1, respectively, for vecuronium; and 31 and 30 micrograms kg-1 and 56 and 60 micrograms kg-1, respectively, for pancuronium. The values showed no significant differences between the respective primed and control groups. Contrary to previous suggestions, our results show no enhancement of blockade when these drugs were administered in divided doses.
构建剂量 - 反应曲线以确定在给予小剂量“预充”剂量的阿曲库铵50微克/千克、维库溴铵10微克/千克或泮库溴铵10微克/千克后，产生50%和95%阻滞（分别）所需的ED50和ED95（剂量）。随后将肌松药作为单次推注给药。将结果与先前发表的关于这些药物的研究进行比较，在先前的研究中未给予预充剂量。对于阿曲库铵，预充组和对照组各自的ED50和ED95值分别为122和126微克/千克以及208和226微克/千克；对于维库溴铵，分别为26和23微克/千克以及42和39微克/千克；对于泮库溴铵，分别为31和30微克/千克以及56和60微克/千克。这些值在各自的预充组和对照组之间没有显示出显著差异。与先前的建议相反，我们的结果表明，当这些药物分剂量给药时，没有增强阻滞作用。
