Gibson F M, Mirakhur R K, Clarke R S, Lavery G G
Br J Anaesth. 1985 Nov;57(11):1060-2. doi: 10.1093/bja/57.11.1060.
The potency of vecuronium was determined using single bolus dose administrations of 10-50 micrograms kg-1 in 28 patients anaesthetized with thiopentone, nitrous oxide, oxygen and fentanyl. The results were compared with those previously obtained using a cumulative dose technique in a comparable group of 10 patients. The 50% and 95% blocking doses (ED50 and ED95) of vecuronium were found to be 23.1 and 39.6 micrograms kg-1, respectively. These were significantly lower than the 30.5 and 56.7 micrograms kg-1 obtained previously using the cumulative dose technique. We recommend the use of single bolus dose method of determining potency for relatively shorter-acting drugs like vecuronium.
在28例接受硫喷妥钠、氧化亚氮、氧气和芬太尼麻醉的患者中，通过单次推注10 - 50微克/千克的维库溴铵来测定其效能。将结果与之前在一组10例可比患者中使用累积剂量技术获得的结果进行比较。发现维库溴铵的50%和95%阻滞剂量（ED50和ED95）分别为23.1和39.6微克/千克。这些值显著低于之前使用累积剂量技术获得的30.5和56.7微克/千克。我们建议使用单次推注剂量法来测定像维库溴铵这样作用相对较短的药物的效能。
