To Study the Vitamin D Levels in Infertile Females and Correlation of Vitamin D Deficiency with AMH Levels in Comparison to Fertile Females.

CONTEXT

Human and animal data suggest that low vitamin D (25-hydroxyvitamin D) status is associated with impaired fertility, endometriosis, and polycystic ovary syndrome. Vitamin D regulates antimullerian hormone (AMH), FSH, mRNA, and expression of genes in reproductive tissues, implicating a role in female reproduction.

AIMS

To study the vitamin D levels in infertile females and to know the correlation of vitamin D deficiency (VDD) with serum AMH in infertile females compare to fertile females.

SETTINGS AND DESIGN

This prospective study was conducted in department of Maternal and Reproductive Health in between April 2014 and April 2016.

MATERIALS AND METHODS

After matching inclusion and exclusion criteria out of total 70 infertile females, 45 were found to have VDD. Of these 35 patients were identified as cases; in whom, the AMH levels were assessed. As control 35 fertile normal females were taken, in which vitamin D and AMH were taken. In both groups, correlation of VDD with AMH was studied.

STATISTICAL ANALYSIS USED

To analyze the correlation between vitamin D and AMH linear regression test and for comparison of both the groups, two sample tests were used.

RESULTS

The VDD was present in 64.28% of infertile females. In vitamin D deficient cases, the mean for vitamin D was 6.18 ± 2.09 and AMH was 1.94 ± 1.30. In vitamin D deficient controls, the mean for vitamin D was 4.85 ± 3.02 and AMH was 3.47 ± 2.59. On comparison, the vitamin D levels were lower in fertile than infertile females, which was significant ( = 0.04), and AMH levels were lower in cases than control group ( = 0.003).

CONCLUSION

The VDD was present in 64.28% of infertile females. No significant correlation was found in between VDD and AMH levels in both the groups.