Eid Basma G, Mosli Hala, Hasan Atif, El-Bassossy Hany M
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Evid Based Complement Alternat Med. 2017;2017:6090269. doi: 10.1155/2017/6090269. Epub 2017 Aug 17.
Prostatic complications are common in patients with diabetes. This study investigated the effect of different ginger ingredients: zingerone, geraniol, and 6-gingerol on the prostate in diabetic rats. Diabetes was induced in Wistar rats by streptozotocin intraperitoneal injection (50 mg/kg), and the rats were left for 10 weeks to develop prostatic complications. In diabetic treated groups, rats received daily oral zingerone, geraniol, and 6-gingerol in doses of 20, 200, and 75 mg/kg, respectively, in the last 8 weeks. Treatment with the compounds caused changes in the ventral prostate of diabetic animals as indicated by the columnar ductal epithelium and dense secretions. There was an amelioration of oxidative stress as evidenced by the lowering of prostate malondialdehyde and elevating prostate oxidized to reduced glutathione (GSH/GSSG) ratios by geraniol and 6-gingerol. None of the three ginger ingredients affected the hyperglycemia, reduction in body weight gain, and testosterone deficiency seen in diabetic animals. Interleukin-1 and interleukin-6 levels remained unchanged. However, zingerone and geraniol ameliorated the fibrosis in diabetic prostate through suppressing the elevated prostate transforming growth factor beta 1 (TGF1) and collagen IV. Therefore, ginger ingredients could be beneficial in alleviating diabetic prostatic complications through suppressing oxidative stress and tissue fibrosis.
前列腺并发症在糖尿病患者中很常见。本研究调查了不同姜成分：姜辣素、香叶醇和6-姜酚对糖尿病大鼠前列腺的影响。通过腹腔注射链脲佐菌素（50mg/kg）诱导Wistar大鼠患糖尿病，并让大鼠持续10周以发展前列腺并发症。在糖尿病治疗组中，大鼠在最后8周分别每日口服剂量为20、200和75mg/kg的姜辣素、香叶醇和6-姜酚。化合物处理导致糖尿病动物腹侧前列腺发生变化，表现为柱状导管上皮和致密分泌物。氧化应激有所改善，这由香叶醇和6-姜酚降低前列腺丙二醛以及提高前列腺氧化型谷胱甘肽与还原型谷胱甘肽（GSH/GSSG）比值所证明。三种姜成分均未影响糖尿病动物出现的高血糖、体重增加减少和睾酮缺乏。白细胞介素-1和白细胞介素-6水平保持不变。然而，姜辣素和香叶醇通过抑制前列腺转化生长因子β1（TGF1）和IV型胶原升高改善了糖尿病前列腺的纤维化。因此，姜成分可能通过抑制氧化应激和组织纤维化对缓解糖尿病前列腺并发症有益。
