替诺福韦所致肾毒性的逆转：两例患者的病例报告
Reversal of tenofovir induced nephrotoxicity: case reports of two patients.
作者信息
Some Fatuma, Koech Mathew, Chesire Emily, Kigen Gabriel
机构信息
Department of Medicine, Moi University School of Medicine, P.O. Box 4606, Eldoret, Kenya.
Moi Teaching and Referral Hospital, P.O. Box 3, Eldoret, Kenya.
出版信息
Pan Afr Med J. 2017 Jun 16;27:126. doi: 10.11604/pamj.2017.27.126.10033. eCollection 2017.
Abstract
The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded that the magnitude may not be that significant. We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir.
摘要
抗逆转录病毒药物替诺福韦的使用与肾毒性有关。然而，这种不良反应的总体影响尚未得到全面评估。一些研究人员报告称，其严重程度足以 warrant 对肾毒性进行监测，而另一些人则得出结论，其严重程度可能并不显著。我们报告了在我们肾脏诊所见到的两例临床病例，患者肌酐水平升高提示肾毒性，停用替诺福韦后恢复正常。 （注：“warrant”此处结合语境似应是“需要、值得”之意，但按要求未添加解释，保留英文原文）
相似文献
1
Reversal of tenofovir induced nephrotoxicity: case reports of two patients.替诺福韦所致肾毒性的逆转：两例患者的病例报告
Pan Afr Med J. 2017 Jun 16;27:126. doi: 10.11604/pamj.2017.27.126.10033. eCollection 2017.
2
Proximal tubular dysfunction in a HIV-1 patient with coadministered tenofovir disoproxil-fumarate and ibuprofen.一名同时服用替诺福韦酯富马酸盐和布洛芬的HIV-1患者出现近端肾小管功能障碍。
AIDS. 2015 Mar 27;29(6):746-8. doi: 10.1097/QAD.0000000000000575.
3
Renal safety of lithium in HIV-infected patients established on tenofovir disoproxil fumarate containing antiretroviral therapy: analysis from a randomized placebo-controlled trial.在接受含富马酸替诺福韦二吡呋酯的抗逆转录病毒治疗的HIV感染患者中锂的肾脏安全性：一项随机安慰剂对照试验的分析
AIDS Res Ther. 2017 Feb 4;14(1):6. doi: 10.1186/s12981-017-0134-2.
4
Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity.评估因肾毒性中断替诺福韦治疗后肾脏标志物进展的前瞻性研究。
Biomed Res Int. 2016;2016:4380845. doi: 10.1155/2016/4380845. Epub 2016 Dec 18.
5
Renal safety of tenofovir disoproxil fumarate.富马酸替诺福韦二吡呋酯的肾脏安全性。
AIDS Read. 2007 Feb;17(2):90-2, 99-104, C3.
6
Long term reference change value of creatinine in HIV-positive patients with anti-retroviral therapy: A new tool in clinical practice.接受抗逆转录病毒治疗的HIV阳性患者肌酐的长期参考变化值：临床实践中的一种新工具。
Clin Biochem. 2015 Jun;48(9):622-4. doi: 10.1016/j.clinbiochem.2015.01.002. Epub 2015 Jan 16.
7
Nonalbumin proteinuria predominates in biopsy-proven tenofovir nephrotoxicity.在经活检证实的替诺福韦肾毒性中，非白蛋白蛋白尿占主导。
AIDS. 2015 May 15;29(8):941-6. doi: 10.1097/QAD.0000000000000628.
8
Key toxicity issues with the WHO-recommended first-line antiretroviral therapy regimen.世界卫生组织推荐的一线抗逆转录病毒治疗方案的关键毒性问题。
Expert Rev Clin Pharmacol. 2016 Nov;9(11):1493-1503. doi: 10.1080/17512433.2016.1221760. Epub 2016 Aug 22.
9
Prevalence and significance of proximal renal tubular abnormalities in HIV-infected patients receiving tenofovir.接受替诺福韦治疗的HIV感染患者近端肾小管异常的患病率及意义
AIDS. 2016 Jan;30(2):231-9. doi: 10.1097/QAD.0000000000000901.
10
Renal Toxicity of Concomitant Exposure to Tenofovir and Inhibitors of Tenofovir's Renal Efflux Transporters in Patients Infected With HIV Type 1.1 型人类免疫缺陷病毒感染患者同时暴露于替诺福韦和替诺福韦肾外排转运蛋白抑制剂的肾毒性。
J Infect Dis. 2016 Feb 15;213(4):561-8. doi: 10.1093/infdis/jiv466. Epub 2015 Sep 23.
引用本文的文献
1
Renal dysfunction among adult HIV/AIDS patients on antiretroviral therapy at a tertiary facility in Ghana.加纳一家三级医疗机构中接受抗逆转录病毒疗法的成年艾滋病毒/艾滋病患者的肾功能障碍。
BMC Nephrol. 2018 Nov 21;19(1):333. doi: 10.1186/s12882-018-1130-z.
本文引用的文献
1
Tenofovir-induced nephrotoxicity: incidence, mechanism, risk factors, prognosis and proposed agents for prevention.替诺福韦诱导的肾毒性：发生率、机制、危险因素、预后及预防建议药物
Eur J Clin Pharmacol. 2014 Sep;70(9):1029-40. doi: 10.1007/s00228-014-1712-z. Epub 2014 Jun 25.
2
Delayed onset renal failure in a patient on tenofovir based antiretroviral regimen.一名接受基于替诺福韦的抗逆转录病毒治疗方案的患者出现延迟性肾衰竭。
Indian J Pharmacol. 2014 Mar-Apr;46(2):230-1. doi: 10.4103/0253-7613.129330.
3
Higher risk of renal impairment associated with tenofovir use amongst people living with HIV in India: a comparative cohort analysis between Western India and United Kingdom.在印度，与使用替诺福韦相关的肾功能损害风险较高：印度西部和英国之间的比较队列分析。
BMC Infect Dis. 2014 Mar 29;14:173. doi: 10.1186/1471-2334-14-173.
4
Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.富尼埃综合征伴肾功能下降与替诺福韦二吡呋酯：HIV 感染患者的预测因素和转归的前瞻性病例对照研究。
PLoS One. 2014 Mar 20;9(3):e92717. doi: 10.1371/journal.pone.0092717. eCollection 2014.
5
The rate of recovery in renal function when patients with HIV infection discontinue treatment with tenofovir.感染HIV的患者停用替诺福韦治疗后肾功能的恢复率。
HIV Med. 2014 Sep;15(8):505-10. doi: 10.1111/hiv.12149. Epub 2014 Mar 18.
6
Tenofovir effect on the kidneys of HIV-infected patients: a double-edged sword?替诺福韦对 HIV 感染患者肾脏的影响：一把双刃剑？
J Am Soc Nephrol. 2013 Oct;24(10):1519-27. doi: 10.1681/ASN.2012080857. Epub 2013 Sep 19.
7
Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study.抗逆转录病毒治疗暴露与基线肾功能正常的 HIV 阳性人群肾功能损害的相关性：D:A:D 研究。
J Infect Dis. 2013 May 1;207(9):1359-69. doi: 10.1093/infdis/jit043. Epub 2013 Feb 4.
8
Incidence of renal toxicity in HIV-infected, antiretroviral-naïve patients starting tenofovir/emtricitabine associated with efavirenz, atazanavir/ritonavir, or lopinavir/ritonavir.开始使用替诺福韦/恩曲他滨并联合依非韦伦、阿扎那韦/利托那韦或洛匹那韦/利托那韦的未接受过抗逆转录病毒治疗的HIV感染患者中肾毒性的发生率。
Scand J Infect Dis. 2013 Feb;45(2):147-54. doi: 10.3109/00365548.2012.712213. Epub 2012 Sep 19.
9
Tenofovir-associated renal dysfunction in clinical practice: An observational cohort from western India.临床实践中与替诺福韦相关的肾功能障碍：来自印度西部的一项观察性队列研究
Indian J Sex Transm Dis AIDS. 2010 Jan;31(1):30-4. doi: 10.4103/0253-7184.68998.
10
Tenofovir nephrotoxicity: 2011 update.替诺福韦肾毒性：2011年更新
AIDS Res Treat. 2011;2011:354908. doi: 10.1155/2011/354908. Epub 2011 Jun 7.
Zotero 插件