Some Fatuma, Koech Mathew, Chesire Emily, Kigen Gabriel
Department of Medicine, Moi University School of Medicine, P.O. Box 4606, Eldoret, Kenya.
Moi Teaching and Referral Hospital, P.O. Box 3, Eldoret, Kenya.
Pan Afr Med J. 2017 Jun 16;27:126. doi: 10.11604/pamj.2017.27.126.10033. eCollection 2017.
The use of the antiretroviral drug tenofovir has been associated with nephrotoxicity. However, the overall impact of this adverse effect has not comprehensively evaluated. Some researchers have reported that it is quite severe to warrant monitoring for renal toxicity, while others have concluded that the magnitude may not be that significant. We report two clinical cases seen in our renal clinic with high creatinine levels suggestive of nephrotoxicity who reverted back to normality upon withdrawal of tenofovir.
抗逆转录病毒药物替诺福韦的使用与肾毒性有关。然而，这种不良反应的总体影响尚未得到全面评估。一些研究人员报告称，其严重程度足以 warrant 对肾毒性进行监测，而另一些人则得出结论，其严重程度可能并不显著。我们报告了在我们肾脏诊所见到的两例临床病例，患者肌酐水平升高提示肾毒性，停用替诺福韦后恢复正常。 （注：“warrant”此处结合语境似应是“需要、值得”之意，但按要求未添加解释，保留英文原文）
