伊朗哈马丹地区人类免疫缺陷病毒感染患者布鲁氏菌病血清阳性率
Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran.
作者信息
Keramat Fariba, Majzobi Mohammad Mehdi, Poorolajal Jalal, Ghane Zohreh Zarei, Adabi Maryam
机构信息
Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Departments of Epidemiology and Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Osong Public Health Res Perspect. 2017 Aug;8(4):282-288. doi: 10.24171/j.phrp.2017.8.4.09. Epub 2017 Aug 31.
OBJECTIVES
Brucellosis is a systemic disease with a wide spectrum of clinical manifestations. This study aimed to determine the seroprevalence of brucellosis in human immunodeficiency virus (HIV) infected patients in Hamadan Province in the west of Iran.
METHODS
A total of 157 HIV-infected patients were screened through standard serological tests, including Wright's test, Coombs' Wright test, and 2-mercaptoethanol agglutination test (2ME test), blood cultures in Castaneda media, and CD4 counting. Data were analyzed using Stata version 11.
RESULTS
Wright and Coombs' Wright tests were carried out, and only 5 (3.2%) patients had positive serological results. However, all patients had negative 2ME results, and blood cultures were negative for spp. Moreover, patients with positive serology and a mean CD4 count of 355.8 ± 203.11 cells/μL had no clinical manifestations of brucellosis, and, and the other patients had a mean CD4 count of 335.55 ± 261.71 cells/μL.
CONCLUSION
Results of this study showed that HIV infection is not a predisposing factor of acquiring brucellosis.
目的
布鲁氏菌病是一种具有广泛临床表现的全身性疾病。本研究旨在确定伊朗西部哈马丹省人类免疫缺陷病毒（HIV）感染患者中布鲁氏菌病的血清流行率。
方法
通过标准血清学检测对157例HIV感染患者进行筛查，包括wright试验、库姆斯wright试验和2-巯基乙醇凝集试验（2ME试验），在卡斯塔涅达培养基中进行血培养，并进行CD4计数。使用Stata 11版对数据进行分析。
结果
进行了wright试验和库姆斯wright试验，只有5例（3.2%）患者血清学结果呈阳性。然而，所有患者2ME结果均为阴性，血培养对布鲁氏菌属均为阴性。血清学阳性且平均CD4计数为355.8±203.11个细胞/μL的患者无布鲁氏菌病临床表现，其他患者平均CD4计数为335.55±261.71个细胞/μL。
结论
本研究结果表明，HIV感染不是获得布鲁氏菌病的 predisposing因素。 （注：“predisposing”未找到合适中文对应，保留英文）
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