Jiang Qiu-Dong, Yang Wen-Guo, Cai Hao, Ma Min, Zhang Hui, Liu Pei, Chen Jun, Duan Jin-Ao
Jiangsu Collaborative Innovation Center of Chinese Medicial Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Pharmaceutial Research Laboratory, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhongguo Zhong Yao Za Zhi. 2016 Jul;41(13):2500-2505. doi: 10.4268/cjcmm20161321.
The results of previous studies showed potential correlations between the penetration enhancement effect of essential oils and the drug properties of traditional Chinese medicine based on the data mining method. As chemical composition is the material basis of drug properties of traditional Chinese medicine, this article further analyzed the correlation between the chemical composition of essential oils and the drug properties. Firstly, essential oils were extracted by steam distillation, and then physicochemical parameters of essential oils, such as relative density and refractive index, were measured. The chemical components of 20 essential oils were analyzed by GC-MS, and divided into 12 categories according to skeleton features and functional groups. Finally, Logistic regression analysis was applied to reveal the correlations. The results proved that five flavors, four tastes and channel tropisms showed the correlation with chemical composition of essential oils (P<0.05). In conclusion, there were obvious correlations and regularity between the drug properties of traditional Chinese medicine and the chemical composition of essential oils.
以往研究结果表明，基于数据挖掘方法，精油的促渗作用与中药药性之间存在潜在关联。由于化学成分是中药药性的物质基础，本文进一步分析了精油化学成分与药性之间的相关性。首先，采用水蒸气蒸馏法提取精油，然后测定精油的相对密度、折光率等理化参数。采用气相色谱-质谱联用仪（GC-MS）分析20种精油的化学成分，并根据骨架特征和官能团分为12类。最后，应用Logistic回归分析揭示相关性。结果表明，五味、四气和归经与精油化学成分存在相关性（P<0.05）。综上所述，中药药性与精油化学成分之间存在明显的相关性和规律性。
