复杂疾病的连锁分析：在家族性阿尔茨海默病中的应用

Linkage analysis of a complex disease: application to familial Alzheimer's disease.

作者信息

Neuman R J, Rice J P, Hampe C L, Burroughs T E, Moldin S O

机构信息

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110-1093.

出版信息

Genet Epidemiol. 1993;10(6):419-24. doi: 10.1002/gepi.1370100615.

DOI:10.1002/gepi.1370100615

PMID:8314037

Abstract

Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 21 was assessed using single-locus and two-locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 21 while an older group showed evidence for linkage to markers on chromosome 19. Two-locus models of disease were used to analyze the youngest group for linkage to pairs of markers on chromosome 21 and an older group with markers on chromosome 19.

摘要

利用单基因座和双基因座遗传模型评估了阿尔茨海默病基因与19号和21号染色体上标记物的连锁证据。家庭根据其发病平均年龄进行分组。最年轻的组在21号染色体上的标记物产生了更高的对数优势分数，而年龄较大的组则显示出与19号染色体上标记物连锁的证据。采用双基因座疾病模型分析最年轻组与21号染色体上标记物对的连锁情况，以及年龄较大组与19号染色体上标记物的连锁情况。