Goldin L R, Gershon E S
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892.
Genet Epidemiol. 1993;10(6):449-54. doi: 10.1002/gepi.1370100620.
Age of onset heterogeneity in Alzheimer's disease families was modelled by allowing for different liability classes for affected individuals according to their age of onset when calculating lod scores to chromosome 21 and chromosome 19 markers. Linkage to chromosome 21 was supported in the Boston data set, and the method of age correction did not greatly change the lod scores when only affected individuals were analyzed. The location of a gene on chromosome 19 for late age of onset illness was affected by the assumptions about early onset individuals.
通过在计算21号染色体和19号染色体标记的对数优势比分数时，根据发病年龄为患病个体设定不同的易患类别，对阿尔茨海默病家族中的发病年龄异质性进行建模。在波士顿数据集中支持与21号染色体的连锁关系，并且当仅分析患病个体时，年龄校正方法并没有使对数优势比分数发生很大变化。关于早发型个体的假设影响了19号染色体上晚发型疾病基因的定位。
