Yates M S, Askey E A, Bowmer C J
Department of Pharmacology, University of Leeds, UK.
J Pharm Pharmacol. 1987 Sep;39(9):711-6. doi: 10.1111/j.2042-7158.1987.tb06974.x.
Cardiovascular responses were determined in rats with chronic renal failure (CRF) produced by five sixths nephrectomy and in sham-operated rats. The conscious systolic blood pressure of rats with CRF was significantly higher than the pressure in controls although, after anaesthesia, there were no significant differences in the mean arterial pressure between the two groups of rats. The pressor responses to noradrenaline in rats with CRF were not significantly different from those recorded in sham-operated controls. The bradycardia elicited by electrical stimulation of the vagus nerve was significantly diminished in rats with CRF. However, indomethacin treatment (1 mg kg-1 s.c. twice daily for 2 days) abolished the differences in response to vagal stimulation. Changes in heart rate in response to electrical stimulation of the cervical sympathetic nerve and to bolus i.v. injections of isoprenaline and carbachol were similar in rats with CRF and controls. The most notable disturbance of cardiovascular function in rats with CRF is the diminished cardiac chronotropic response to vagal stimulation which appears to be mediated by a presynaptic action of prostaglandins.
通过六分之五肾切除术制备慢性肾衰竭（CRF）大鼠模型，并与假手术大鼠一起测定心血管反应。CRF大鼠清醒时的收缩压显著高于对照组，然而，麻醉后，两组大鼠的平均动脉压无显著差异。CRF大鼠对去甲肾上腺素的升压反应与假手术对照组记录的反应无显著差异。电刺激迷走神经引起的心动过缓在CRF大鼠中显著减弱。然而，吲哚美辛治疗（1mg/kg皮下注射，每日两次，共2天）消除了对迷走神经刺激反应的差异。CRF大鼠和对照组对颈交感神经电刺激以及静脉推注异丙肾上腺素和卡巴胆碱的心率变化相似。CRF大鼠最显著的心血管功能紊乱是对迷走神经刺激的心脏变时反应减弱，这似乎是由前列腺素的突触前作用介导的。
