Bowmer C J, Nichols A J, Warren M, Yates M S
Br J Pharmacol. 1983 Jun;79(2):471-6. doi: 10.1111/j.1476-5381.1983.tb11020.x.
Autonomic and cardiovascular function were assessed in rats with glycerol-induced acute renal failure (ARF). Rats with ARF had significantly lower mean arterial blood pressure and heart rates and significantly elevated plasma noradrenaline concentrations. The chronotropic responses to right cervical sympathetic and vagal stimulation were diminished in rats with ARF. The pressor and depressor responses to noradrenaline and nitroprusside respectively when expressed as a change in mmHg pressure were significantly reduced in rats with ARF when compared to controls. However, when the depressor responses to nitroprusside were expressed as a percentage fall in basal mean arterial pressure, with the exception of the response to a dose of 10 micrograms kg-1, there were no significant differences between control and uraemic rats. The present findings show that in the rat, changes in cardiovascular responsiveness occur after a brief period of uraemia which are similar to those observed in patients and rats with chronic renal failure.
对甘油诱导的急性肾衰竭（ARF）大鼠的自主神经和心血管功能进行了评估。ARF大鼠的平均动脉血压和心率显著降低，血浆去甲肾上腺素浓度显著升高。ARF大鼠对右颈交感神经和迷走神经刺激的变时反应减弱。与对照组相比，ARF大鼠对去甲肾上腺素和硝普钠的升压和降压反应（以mmHg压力变化表示）显著降低。然而，当硝普钠的降压反应以基础平均动脉压下降的百分比表示时，除了对10微克/千克剂量的反应外，对照组和尿毒症大鼠之间没有显著差异。目前的研究结果表明，在大鼠中，尿毒症短时间后会出现心血管反应性变化，这与慢性肾衰竭患者和大鼠中观察到的变化相似。
