Yates M S, Askey E A, Wilmot S E, Bowmer C J
J Pharm Pharmacol. 1986 Jan;38(1):59-62. doi: 10.1111/j.2042-7158.1986.tb04469.x.
Cardiac chronotropic responses to isoprenaline, carbachol and electrical stimulation of the cervical sympathetic and vagal nerves were recorded in rats with glycerol-induced acute renal failure (ARF) and control rats. The experiments involving electrical stimulation of cardiac nerves were performed in rats which either had been pretreated with indomethacin (1 mg kg-1 twice daily for 2 days) or had undergone acute bilateral renal pedicle ligation. The findings from this investigation indicate that the reduced chronotropic responses to vagal stimulation in rats with glycerol-induced ARF are due to a reduction in acetylcholine release mediated by prostaglandins possibly originating from the damaged kidneys. The diminished response to cervical sympathetic stimulation results from a decreased postsynaptic response to beta-adrenoceptor stimulation.
在甘油诱导的急性肾衰竭（ARF）大鼠和对照大鼠中记录了对异丙肾上腺素、卡巴胆碱以及颈交感神经和迷走神经电刺激的心脏变时反应。涉及心脏神经电刺激的实验在以下大鼠中进行：要么用吲哚美辛预处理（1 mg/kg，每日两次，共2天），要么进行急性双侧肾蒂结扎。本研究结果表明，甘油诱导的ARF大鼠对迷走神经刺激的变时反应降低是由于前列腺素介导的乙酰胆碱释放减少，前列腺素可能源自受损的肾脏。对颈交感神经刺激反应减弱是由于对β-肾上腺素能受体刺激的突触后反应降低。
