Yates M S, Critchley M A, Askey E A, Bowmer C J
J Pharm Pharmacol. 1985 Mar;37(3):175-9. doi: 10.1111/j.2042-7158.1985.tb05035.x.
Cardiac reactivity has been determined in rats with acute renal failure (ARF) induced by either bilateral nephrectomy or intramuscular glycerol injection. Rats with bilateral nephrectomy showed reduced chronotropic responses to cervical sympathetic stimulation but no appreciable alteration in the chronotropic responses to vagal stimulation. By contrast, we have previously noted that rats with glycerol-induced ARF show diminished chronotropic responses to stimulation of both nerves. The negative chronotropic and inotropic responses to carbachol in isolated atria from both nephrectomized and glycerol-injected rats were not significantly different from their respective controls. In both models of ARF the atrial positive chronotropic responses to isoprenaline were significantly decreased whilst positive inotropic responses were not significantly different from controls. The results indicate that the cause of the reduced chronotropic response to vagal stimulation observed in glycerol-injected rats is of presynaptic origin whilst the reduced chronotropic response to cervical sympathetic stimulation noted in both models of ARF may be due to an impaired postsynaptic response.
通过双侧肾切除或肌肉注射甘油诱导大鼠急性肾衰竭（ARF），并测定其心脏反应性。双侧肾切除的大鼠对颈交感神经刺激的变时反应降低，但对迷走神经刺激的变时反应无明显改变。相比之下，我们之前注意到甘油诱导的ARF大鼠对两种神经刺激的变时反应均减弱。肾切除和注射甘油的大鼠分离心房对卡巴胆碱的负性变时和变力反应与其各自的对照组无显著差异。在两种ARF模型中，心房对异丙肾上腺素的正性变时反应均显著降低，而正性变力反应与对照组无显著差异。结果表明，注射甘油的大鼠中观察到的对迷走神经刺激变时反应降低的原因是突触前起源，而在两种ARF模型中均观察到的对颈交感神经刺激变时反应降低可能是由于突触后反应受损。
