a State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering , Nanjing Tech University , Nanjing , P.R. China.
b Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) , Nanjing Tech University , Nanjing , P.R. China.
Crit Rev Biotechnol. 2018 Jun;38(4):529-540. doi: 10.1080/07388551.2017.1376309. Epub 2017 Sep 14.
Butanol is an important bulk chemical and has been regarded as an advanced biofuel. Large-scale production of butanol has been applied for more than 100 years, but its production through acetone-butanol-ethanol (ABE) fermentation process by solventogenic Clostridium species is still not economically viable due to the low butanol titer and yield caused by the toxicity of butanol and a by-product, such as acetone. Renewed interest in biobutanol as a biofuel has spurred technological advances to strain modification and fermentation process design. Especially, with the development of interdisciplinary processes, the sole product or even the mixture of ABE produced through ABE fermentation process can be further used as platform chemicals for high value added product production through enzymatic or chemical catalysis. This review aims to comprehensively summarize the most recent advances on the conversion of acetone, butanol and ABE mixture into various products, such as isopropanol, butyl-butyrate and higher-molecular mass alkanes. Additionally, co-production of other value added products with ABE was also discussed.
丁醇是一种重要的大宗化学品，一直被视为先进的生物燃料。其大规模生产已经应用了 100 多年，但由于溶剂性梭菌产生的丁醇的毒性和副产物（如丙酮）的存在，导致丁醇的浓度和产率较低，通过丙酮丁醇乙醇（ABE）发酵工艺生产仍然不具有经济性。作为生物燃料，生物丁醇再次受到关注，促使技术进步对菌株进行改良和发酵工艺进行设计。特别是，随着交叉学科工艺的发展，通过 ABE 发酵工艺生产的单一产品甚至 ABE 混合物，可通过酶或化学催化进一步用作平台化学品，用于生产高附加值产品。本综述旨在全面总结将丙酮、丁醇和 ABE 混合物转化为各种产品（如异丙醇、丁酸丁酯和高分子量烷烃）的最新进展。此外，还讨论了与 ABE 联产其他高附加值产品的情况。
