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原发性输卵管癌:一种术中被误诊为良性卵巢肿瘤的极其罕见的妇科癌症:病例报告

Primary Fallopian Tube Carcinoma: An Extremely Rare Gynecological Cancer Misdiagnosed Intraoperatively as Benign Ovarian Neoplasm: A Case Report.

作者信息

Thanasa Efthymia, Stamouli Dimitra, Gerokostas Ektoras-Evangelos, Balafa Konstantina, Koutalia Nikoleta, Thanasas Ioannis

机构信息

Department of Health Sciences, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Department of Obstetrics and Gynecology, General Hospital in Trikala, Efkli 33, 42100 Trikala, Greece.

出版信息

Clin Pract. 2022 Apr 22;12(3):253-260. doi: 10.3390/clinpract12030030.

DOI:10.3390/clinpract12030030
PMID:35645307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9150006/
Abstract

Primary fallopian tube carcinoma is very rare. Diagnosis is challenging. The description of our case concerns an asymptomatic 71-year-old patient who came for a routine gynecological examination. Imaging of the pelvis revealed the presence of a two-chambered cystic formation in the anatomical position of the right ovary. It was decided to investigate the disease by laparotomy. Examination of the frozen section from the site of the cystic lesion was negative for malignancy. An abdominal total hysterectomy was performed with bilateral salpingo-oophorectomy. Serous carcinoma of the fallopian tube was diagnosed postoperatively by histological examination of the surgical preparation. Immediately after surgery, the patient's health was good.The patient was referred to an oncology center and was monitored. Chemotherapy based on platinum and taxane was recommended. Six months after the operation the patient is in good health. The possibility of a second surgery to treat fallopian tube cancer with pelvic lymph node dissectionis under discussion and is expected to be decided by oncologists and gynecologists-oncologists. In this article, after describing the case report, a brief review of this rare entity disease's diagnostic and therapeutic approach is attempted.

摘要

原发性输卵管癌非常罕见。诊断具有挑战性。我们病例的描述涉及一名71岁无症状患者,她前来进行常规妇科检查。盆腔成像显示在右卵巢的解剖位置存在一个双腔囊性结构。决定通过剖腹手术对该疾病进行调查。对囊性病变部位的冰冻切片检查未发现恶性肿瘤。进行了腹式全子宫切除术及双侧输卵管卵巢切除术。术后通过对手术标本的组织学检查诊断为输卵管浆液性癌。手术后患者立即恢复良好。患者被转诊至肿瘤中心并接受监测。建议采用基于铂类和紫杉烷的化疗。术后六个月患者健康状况良好。关于进行二次手术以治疗输卵管癌并进行盆腔淋巴结清扫的可能性正在讨论中,预计将由肿瘤学家和妇科肿瘤学家做出决定。在本文中,在描述病例报告后,尝试对这种罕见实体疾病的诊断和治疗方法进行简要综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/eb576941fc3c/clinpract-12-00030-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/9f5628a32921/clinpract-12-00030-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/0e7165cb1ef3/clinpract-12-00030-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/eb576941fc3c/clinpract-12-00030-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/9f5628a32921/clinpract-12-00030-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/0e7165cb1ef3/clinpract-12-00030-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c783/9150006/eb576941fc3c/clinpract-12-00030-g003a.jpg

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本文引用的文献

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Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1(Suppl 1):61-85. doi: 10.1002/ijgo.13878.
2
PRACTICAL MEANS OF PREOPERATIVE DIAGNOSTICS OF PRIMARY FALLOPIAN TUBE CANCER.原发性输卵管癌的术前诊断实用方法。
Wiad Lek. 2021;74(2):282-287.
3
Feasibility of neoadjuvant and adjuvant intraperitoneal chemotherapy in patients with advanced epithelial ovarian cancer: A single-center experience.晚期上皮性卵巢癌患者新辅助和辅助腹腔内化疗的可行性:单中心经验
Medicine (Baltimore). 2020 Sep 4;99(36):e22100. doi: 10.1097/MD.0000000000022100.
4
Use of ablation and ultrasonic aspiration at primary debulking surgery in advanced stage ovarian, fallopian tube, and primary peritoneal cancer.在晚期卵巢癌、输卵管癌和原发性腹膜癌的初次肿瘤细胞减灭术中使用消融和超声吸引术。
Int J Gynecol Cancer. 2020 Jul;30(7):1052-1057. doi: 10.1136/ijgc-2020-001466. Epub 2020 Jun 2.
5
MRI can be used to differentiate between primary fallopian tube carcinoma and epithelial ovarian cancer.MRI 可用于区分原发性输卵管癌和上皮性卵巢癌。
Clin Radiol. 2020 Jun;75(6):457-465. doi: 10.1016/j.crad.2020.02.002. Epub 2020 Mar 9.
6
Incidence of germline BRCA1/2 mutations in women with tubo-ovarian high-grade serous carcinomas with and without serous tubal intra-epithelial carcinomas.BRCA1/2 种系突变在伴有和不伴有输卵管上皮内浆液性癌的输卵管-卵巢高级别浆液性癌患者中的发生率。
Int J Gynecol Cancer. 2020 Jan;30(1):94-99. doi: 10.1136/ijgc-2019-000540. Epub 2019 Nov 7.
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