Institut für Chemie und Biochemie, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
Institut für Biologie, Freie Universität Berlin , Königin-Luise-Str. 1-3, 14195 Berlin, Germany.
ACS Appl Mater Interfaces. 2017 Oct 11;9(40):35411-35418. doi: 10.1021/acsami.7b10541. Epub 2017 Sep 27.
A novel surface coating with durable broad-spectrum antibacterial ability was prepared based on mussel-inspired dendritic polyglycerol (MI-dPG) embedded with copper nanoparticles (Cu NPs). The functional surface coating is fabricated via a facile dip-coating process followed by in situ reduction of copper ions with a MI-dPG coating to introduce Cu NPs into the coating matrix. This coating has been demonstrated to possess efficient long-term antibacterial properties against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and kanamycin-resistant E. coli through an "attract-kill-release" strategy. The synergistic antibacterial activity of the coating was shown by the combination of two functions of the contact killing, reactive oxygen species production and Cu ions released from the coating. Furthermore, this coating inhibited biofilm formation and showed good compatibility to eukaryotic cells. Thus, this newly developed Cu NP-incorporated MI-dPG surface coating may find potential application in the design of antimicrobial coating, such as implantable devices.
一种基于贻贝类灵感的树枝状聚甘油(MI-dPG)嵌入铜纳米粒子(Cu NPs)的具有耐用广谱抗菌能力的新型表面涂层被制备。该功能表面涂层是通过简单的浸涂工艺制备的,然后用 MI-dPG 涂层原位还原铜离子,将 Cu NPs 引入涂层基质中。该涂层通过“吸引-杀死-释放”策略被证明对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)和耐卡那霉素的大肠杆菌具有有效的长期抗菌性能。通过涂层的接触杀灭、活性氧物质的产生和 Cu 离子的释放这两种功能的协同作用,显示出了该涂层的协同抗菌活性。此外,该涂层抑制生物膜的形成,并与真核细胞具有良好的相容性。因此,这种新开发的含有 Cu NP 的 MI-dPG 表面涂层可能在设计抗菌涂层方面具有潜在的应用,如植入式装置。