Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
Langmuir. 2022 Jun 14;38(23):7157-7167. doi: 10.1021/acs.langmuir.2c00353. Epub 2022 May 30.
Bacterial infections and limited surface lubrication are the two key challenges for bioimplants in dynamic contact with tissues. However, the simultaneous lubricating and antibacterial properties of the bioimplants have rarely been investigated. In this work, we successfully developed a multifunctional coating with simultaneous antibacterial and lubricating properties for surface functionalization of bioimplant materials. The multifunctional coating was fabricated on a polyurethane (PU) substrate via polydopamine (PDA)-assisted multicomponent codeposition, containing polyethyleneimine (PEI) and trace amounts of copper (Cu) as synergistic antibacterial components and zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the lubricating component. The obtained PDA(Cu)/PEI/PMPC coating showed excellent antibacterial activity (antibacterial efficiency: ∼99%) to both and compared with bare PU. The excellent antibacterial properties were attributed to the combined effect of anti-adhesion capability of hydrophilic PMPC and PEI and bactericidal activity of Cu in the coating. Meanwhile, the coefficient of friction of the coating was significantly decreased by ∼52% compared with bare PU owing to the high hydration feature of PMPC, suggesting the superior lubricating property. Furthermore, the PDA(Cu)/PEI/PMPC coating was highly biocompatible toward human umbilical vein endothelial cells demonstrated by cytotoxicity tests. This study not only contributes to the chemistry of PDA-assisted multicomponent codeposition but also provides a facile and practical way for rational design of multifunctional coatings for medical devices.
细菌感染和有限的表面润滑是与组织动态接触的生物植入物面临的两个关键挑战。然而，生物植入物的同时润滑和抗菌性能很少被研究。在这项工作中，我们成功地开发了一种具有同时抗菌和润滑性能的多功能涂层，用于生物植入材料的表面功能化。该多功能涂层是通过聚多巴胺（PDA）辅助的多组分共沉积在聚氨酯（PU）基底上制备的，其中包含聚乙烯亚胺（PEI）和痕量的铜（Cu）作为协同抗菌成分，两性离子聚（2-甲基丙烯酰氧基乙基磷酸胆碱）（PMPC）作为润滑成分。所获得的 PDA(Cu)/PEI/PMPC 涂层表现出优异的抗菌活性（抗菌效率：~99%），对 和 均有很好的抑制效果，优于裸 PU。优异的抗菌性能归因于涂层中亲水 PMPC 和 PEI 的抗粘附能力以及铜的杀菌活性的协同作用。同时，由于 PMPC 的高水合特性，涂层的摩擦系数比裸 PU 显著降低了约 52%，表明其具有优异的润滑性能。此外，通过细胞毒性试验证明，PDA(Cu)/PEI/PMPC 涂层对人脐静脉内皮细胞具有高度的生物相容性。这项研究不仅为 PDA 辅助的多组分共沉积化学做出了贡献，也为医疗器械多功能涂层的合理设计提供了一种简单实用的方法。
