MiR-451作为一种新的胃癌肿瘤标志物。
MiR-451 as a new tumor marker for gastric cancer.
作者信息
Shen Yong, Gong Jiao-Mei, Zhou Li-Li, Sheng Jia-He
机构信息
Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Pathology and Pathophysiology, Medical School of Southeast University, Nanjing, Jiangsu, China.
出版信息
Oncotarget. 2017 Apr 19;8(34):56542-56545. doi: 10.18632/oncotarget.17239. eCollection 2017 Aug 22.
Gastric cancer is the second most common malignancy in China. However, the prognosis for gastric cancer patients remains poor. The purpose of this study was to investigate whether miR-451 was a potential prognostic biomarker for gastric cancer. Fresh tissues were immediately frozen in liquid nitrogen until use. The plasma was extracted and quantitative real-time polymerase chain reaction was performed to detect miR-451 expression. The Student's t test analysis and multivariate Cox regression analysis were performed to analyze expression of miR-451. The analysis results showed that the expression level of miR-451 was decreased expression in gastric cancer tissue. The down-regulation of miR-451 tended to be positively correlated with tumor stage, lymphatic metastasis and shorter overall survival of patients. MiR-451 may be a potential biomarker and a potential therapeutic target for the diagnoses and prognosis of gastric cancer.
胃癌是中国第二大常见恶性肿瘤。然而，胃癌患者的预后仍然很差。本研究的目的是调查miR-451是否为胃癌潜在的预后生物标志物。新鲜组织立即在液氮中冷冻备用。提取血浆并进行定量实时聚合酶链反应以检测miR-451的表达。采用Student's t检验分析和多因素Cox回归分析来分析miR-451的表达。分析结果显示，miR-451在胃癌组织中的表达水平降低。miR-451的下调往往与肿瘤分期、淋巴转移及患者较短的总生存期呈正相关。miR-451可能是胃癌诊断和预后的潜在生物标志物及潜在治疗靶点。
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