[克洛非林对麻醉性镇痛药镇痛及自主神经作用的影响]
[Influence of klofelin on the analgesic and autonomotropic effects of narcotic analgesics].
作者信息
Panov A V
出版信息
Farmakol Toksikol. 1987 Sep-Oct;50(5):18-21.
PMID:2891563
Abstract
In conscious rats clopheline (0.1-0.25 mg/kg), in contrast to promedol, morphine and fentanyl administered at analgesic doses, suppressed nociceptive reactions of arterial blood pressure produced by a mechanical stimulation and intracardiac infusion of bradykinin. The use of clopheline in combination with narcotic analgesics potentiated the analgesic effect and significantly inhibited nociceptive hemodynamic reactions without changing the background level of arterial blood pressure.
摘要
与以镇痛剂量给药的普罗美多、吗啡和芬太尼不同，在清醒大鼠中，氯菲林（0.1 - 0.25毫克/千克）可抑制机械刺激和心内输注缓激肽所产生的动脉血压伤害性反应。将氯菲林与麻醉性镇痛药联合使用可增强镇痛效果，并在不改变动脉血压背景水平的情况下显著抑制伤害性血流动力学反应。
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