Ignatov Iu D, Miasnikov A A
Eksp Klin Farmakol. 1993 Jul-Aug;56(4):6-9.
Rat experiments have revealed that gradual increases in atmospheric pressure up to 1.1 MPa progressively alters the vocalization threshold in electrical stimulation of the tail root. Substitution of air for heliox (79.1% helium and 20.9% oxygen) leads to attenuation of the analgesic effect of hyperbarism. It is postulated that hyperbaric analgesia is due mainly to the elevated partial pressure of nitrogen. Morphine and promedol in doses of 2.5 mg/kg and clofeline in a dose of 0.1 mg failed to change analgesic effects when atmospheric pressure was increased up to 0.7 and 1.1 MPa. The analgesic effect of morphine and promedol in doses of 5 mg/kg and buprenorphine in a dose of 0.035 mg/kg under similar conditions increased during the whole period of isopression, while that of clofeline in a dose of 0.5 mg/kg increased only in the first few minutes of isopression. The analgesic action of morphoeceptine in a dose of 5 mg/kg decreased during isopression. The possible mechanisms of hyperbaric analgesia and the specific features of the analgesic action of different drugs at elevated atmospheric pressure are discussed.
大鼠实验表明，大气压力逐渐升高至1.1兆帕时，会逐渐改变电刺激尾根时的发声阈值。用氦氧混合气（79.1%氦气和20.9%氧气）替代空气会导致高压氧疗法镇痛效果减弱。据推测，高压镇痛主要归因于氮气分压升高。当大气压力升高至0.7和1.1兆帕时，2.5毫克/千克剂量的吗啡和异丙嗪以及0.1毫克剂量的氯苯乙脒未能改变镇痛效果。在类似条件下，5毫克/千克剂量的吗啡和异丙嗪以及0.035毫克/千克剂量的丁丙诺啡的镇痛效果在等压期间的整个阶段都有所增强，而0.5毫克/千克剂量的氯苯乙脒的镇痛效果仅在等压的最初几分钟有所增强。5毫克/千克剂量的吗啡受体激动剂在等压期间的镇痛作用减弱。本文讨论了高压镇痛的可能机制以及不同药物在升高的大气压力下镇痛作用的具体特点。
