Metin Simon Arda, Lee Brian W, Lambert William Clark, Parish Lawrence Charles
Cambridge University School of Clinical Medicine, Cambridge, United Kingdom.
Department of Dermatology, Rutgers-New Jersey Medical School, University Hospital, Newark, New Jersey.
Clin Dermatol. 2017 Sep-Oct;35(5):491-496. doi: 10.1016/j.clindermatol.2017.06.001. Epub 2017 Jun 8.
Dermatosis papulosa nigra was first described by Aldo Castellani (1874-1971) more than 90 years ago, and it has since been presumed to be a variant of seborrheic keratosis. Despite their morphologic similarities both macroscopically and microscopically, key differences have yet to be explained. These lesions also exhibit different demographics, with dermatosis papulosa nigra having a predilection for dark-skinned individuals and a female predominance. No studies to date have investigated this, but studies assessing the mechanisms of similar dermatologic conditions may yield significant clues. The additional impact of environmental factors may also be important, but much controversy exists. Further investigations into dermatosis papulosa nigra are necessary to determine its pathogenesis and whether it should be regarded as a distinct entity.
90多年前，阿尔多·卡斯特拉尼（1874 - 1971）首次描述了黑色丘疹性皮病，自那时起，它一直被认为是脂溢性角化病的一种变体。尽管它们在宏观和微观上形态相似，但关键差异尚未得到解释。这些损害在人群分布上也有所不同，黑色丘疹性皮病好发于肤色较深的个体，且女性居多。迄今为止尚无研究对此进行调查，但评估类似皮肤病机制的研究可能会提供重要线索。环境因素的额外影响可能也很重要，但存在很多争议。有必要对黑色丘疹性皮病进行进一步研究，以确定其发病机制以及它是否应被视为一种独特的疾病。
