Department of Dermatology, Graduate School of Medicine, University of Toyama, Toyama, Japan.
J Cosmet Dermatol. 2020 Oct;19(10):2572-2575. doi: 10.1111/jocd.13309. Epub 2020 Jan 28.
Dermatosis papulosa nigra (DPN) is characterized by the presence of multiple, small, hyperpigmented, warty papules affecting the face, neck, and trunk that bear to histological semblance to seborrheic keratosis. Although the lesions are benign tumors, they can cause distress for cosmetic reasons.
We, herein, report the cases of three female Japanese patients (mean age, 46 years) with DPN who were treated using a carbon dioxide (CO ) laser with a computerized scanner. The patients were all suffering from an increased number of brown asymptomatic papules (size, 1-5 mm), which were located all over the trunk. Histological examinations revealed acanthosis, hyperkeratosis and horn cyst formation in the epidermis.
We performed CO laser (LASER 30C; Lumenis Inc) treatment (settings: 8-10 W; pulse duration, 0.05-seconds; rest duration, 0.36 seconds; laser spot size, 1.2 mm) for 5-10 months.
With CO laser treatment, were could completely remove the lesions and achieve excellent cosmetic results without scar formation in all cases. The treated lesions did not relapse for more than 1 year.
In our opinion, CO laser treatment with a computerized scanner is an effective therapeutic option for DPN.
黑棘皮病（DPN）的特征是存在多个小的、色素沉着过度的疣状丘疹，影响面部、颈部和躯干，其组织学表现类似于脂溢性角化病。虽然这些病变是良性肿瘤，但由于美容原因，它们可能会引起不适。
我们在此报告三例日本女性患者（平均年龄 46 岁）患有 DPN，使用具有计算机扫描仪的二氧化碳（CO）激光进行治疗。这些患者均患有数量增多的棕色无症状丘疹（大小为 1-5 毫米），这些丘疹分布于整个躯干。组织学检查显示表皮棘层肥厚、角化过度和角囊肿形成。
我们对患者进行 CO 激光（LASER 30C；Lumenis Inc）治疗（设置：8-10 W；脉冲持续时间 0.05 秒；休止持续时间 0.36 秒；激光光斑大小 1.2 毫米），持续 5-10 个月。
在所有患者中，CO 激光治疗可完全去除病变，且不会形成疤痕，获得极佳的美容效果。治疗后的病变 1 年以上未复发。
我们认为，具有计算机扫描仪的 CO 激光治疗是 DPN 的一种有效治疗选择。
