Murota Hiroyuki, Lingli Yang, Katayama Ichiro
Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.
Cell Mol Life Sci. 2017 Dec;74(23):4321-4328. doi: 10.1007/s00018-017-2647-1. Epub 2017 Sep 15.
Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. In this process, changes in the components of the extracellular matrix are required to provide an environment that facilitates tissue remodeling. Among these extracellular matrix components, periostin, a glycoprotein that is predominantly secreted from dermal fibroblasts, has attracted attention. Periostin localizes in the papillary dermis of normal skin, and is aberrantly expressed in the dermis of lesional skin in atopic dermatitis, scar, systemic/limited scleroderma, melanoma, cutaneous T cell lymphoma, and skin damage caused by allergic/autoimmune responses. Periostin induces processes that result in the development of dermal fibrosis, and activate or protract the immune response. The aim of this review was to summarize recent knowledge of the role of periostin in the pathogenesis of dermatoses, and to explore whether periostin is a potential therapeutic target for skin diseases.
皮肤是一个易受外部损伤、慢性炎症和自身免疫损害的器官。组织损伤会导致病变皮肤中细胞的形态和类型发生改变。这种现象称为组织重塑，是由程序性细胞死亡、炎症、免疫紊乱以及肿瘤发生、肿瘤增殖和细胞减灭活性引发的一种普遍的生物学反应。在这个过程中，需要细胞外基质成分发生变化，以提供一个促进组织重塑的环境。在这些细胞外基质成分中，骨膜蛋白这种主要由真皮成纤维细胞分泌的糖蛋白引起了人们的关注。骨膜蛋白定位于正常皮肤的乳头层真皮，在特应性皮炎、瘢痕、系统性/局限性硬皮病、黑色素瘤、皮肤T细胞淋巴瘤以及由过敏/自身免疫反应引起的皮肤损伤的病变皮肤真皮中异常表达。骨膜蛋白诱导导致真皮纤维化发展的过程，并激活或延长免疫反应。这篇综述的目的是总结骨膜蛋白在皮肤病发病机制中作用的最新知识，并探讨骨膜蛋白是否是皮肤疾病的潜在治疗靶点。
