Deshwal Rajesh, Qureshi Md Ishaque, Singh Raj
Department of Medicine, Military Hospital, Agra, Uttar Pradesh.
J Assoc Physicians India. 2015 Dec;63(12):30-32.
Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality. This study was designed to assess the clinical and biochemical parameters of dengue fever patients.
Prospective observational study was undertaken among adult patients in a military hospital. Five hundred fiteen patients were studied and analysed. All patients who were NS1 antigen/IgM dengue positive were included in the study. Clinical features, hematological and biochemical parameters were noted.
Of the 515 patients studied, majority were males (72.81%). Fever was the major symptom (100%) followed by headache (94.75%), myalgia (90.67%), retroorbital pain (18.25%), conjunctival injection (39.41%), rash (37.86%), abdominal pain (24.46%), pleural effusion (20%) and ascites (16.31%). Significant derangements in platelet (69.51%), leucocyte counts (20.19%) and serum transaminases (88.54%) were noted. Mortality rate was 0.77%.
Fever associated with headache, retroorbital pain, erythematous morbilliform rash, conjunctival suffusion and itching in palms and soles along with thrombocytopenia, leucopenia, elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have little role in management of dengue patients.
登革热是报道中最常见的虫媒病毒介导的疫情之一，其发病率逐年上升，具有相当高的发病率和死亡率。本研究旨在评估登革热患者的临床和生化参数。
在一家军队医院对成年患者进行前瞻性观察研究。对515例患者进行了研究和分析。所有NS1抗原/IgM登革热阳性的患者均纳入研究。记录临床特征、血液学和生化参数。
在研究的515例患者中，大多数为男性（72.81%）。发热是主要症状（100%），其次是头痛（94.75%）、肌痛（90.67%）、眶后疼痛（18.25%）、结膜充血（39.41%）、皮疹（37.86%）、腹痛（24.46%）、胸腔积液（20%）和腹水（16.31%）。血小板（69.51%）、白细胞计数（20.19%）和血清转氨酶（88.54%）有显著异常。死亡率为0.77%。
发热伴头痛、眶后疼痛、红斑麻疹样皮疹、结膜充血以及手掌和脚底瘙痒，同时伴有血小板减少、白细胞减少、肝转氨酶升高，应提示临床医生考虑登革热感染的可能性。血小板输注在登革热患者的治疗中作用不大。
