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遗传亲缘关系与“三亲 IVF”的权利

Genetic affinity and the right to 'three-parent IVF'.

机构信息

Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Block MD 11 #02-03, 10 Medical Drive, Singapore, 117597, Singapore.

出版信息

J Assist Reprod Genet. 2017 Dec;34(12):1577-1580. doi: 10.1007/s10815-017-1046-8. Epub 2017 Sep 18.

DOI:10.1007/s10815-017-1046-8
PMID:28920184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5714827/
Abstract

With the recent report of a live birth after use of mitochondrial replacement therapy, sometimes called 'three-parent IVF', the clinical application of the technique is fast becoming a reality. While the United Kingdom allows the procedure under regulatory scrutiny, it remains effectively outlawed in many other countries. We argue that such prohibitions may violate individuals' procreative rights, grounded in individuals' interest in genetic affinity. The interest in genetic affinity was recently endorsed by Singapore's highest court, reflecting an emphasis on the importance of biological ties found across the globe. We apply that reasoning to make the case for a right to 'three-parent IVF'.

摘要

随着最近一份使用线粒体替代疗法(有时称为“三亲 IVF”)后诞生活婴的报告的发布,该技术的临床应用正迅速成为现实。虽然英国在监管审查下允许该程序,但在许多其他国家,该程序实际上仍被禁止。我们认为,这种禁止可能侵犯了个人的生育权利,这些权利基于个人对遗传亲和力的利益。遗传亲和力的利益最近得到了新加坡最高法院的认可,反映了全球范围内对生物联系重要性的重视。我们运用这一推理来论证“三亲 IVF”的权利。

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Genetic affinity and the right to 'three-parent IVF'.遗传亲缘关系与“三亲 IVF”的权利
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Overcoming bioethical, legal, and hereditary barriers to mitochondrial replacement therapy in the USA.克服美国线粒体替代疗法中的生物伦理、法律和遗传障碍。
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本文引用的文献

1
Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.通过卵母细胞纺锤体转移实现活产以预防线粒体疾病。
Reprod Biomed Online. 2017 Apr;34(4):361-368. doi: 10.1016/j.rbmo.2017.01.013.
2
First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation.线粒体替代疗法纺锤体移植后的首例分娩:希望与担忧
Reprod Biomed Online. 2017 Apr;34(4):333-336. doi: 10.1016/j.rbmo.2017.02.004.
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Mitochondrial Replacement Therapy: Unmade in the USA.线粒体替代疗法:美国未生产
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The Mitochondrial Replacement 'Therapy' Myth.线粒体替代“疗法”的神话。
Bioethics. 2017 Jun;31(5):368-374. doi: 10.1111/bioe.12332. Epub 2016 Dec 30.
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Human Nuclear Genome Transfer (So-Called Mitochondrial Replacement): Clearing the Underbrush.人类核基因组转移(所谓的线粒体替代):清理障碍。
Bioethics. 2017 Jan;31(1):7-19. doi: 10.1111/bioe.12309.
6
What Is the Value of Three-Parent IVF?三亲试管婴儿的价值是什么?
Hastings Cent Rep. 2016 Jul;46(4):38-47. doi: 10.1002/hast.594. Epub 2016 May 19.
7
Mitochondrial Replacement Techniques--Implications for the Clinical Community.线粒体替代技术——对临床界的影响
N Engl J Med. 2016 Mar 24;374(12):1103-6. doi: 10.1056/NEJMp1600893. Epub 2016 Feb 24.
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Social and ethical issues in mitochondrial donation.线粒体捐赠中的社会与伦理问题。
Br Med Bull. 2015 Sep;115(1):173-82. doi: 10.1093/bmb/ldv037.
9
Mitochondrial replacement therapy in reproductive medicine.生殖医学中的线粒体替代疗法。
Trends Mol Med. 2015 Feb;21(2):68-76. doi: 10.1016/j.molmed.2014.12.001. Epub 2014 Dec 10.
10
Controversies concerning mitochondrial replacement therapy.关于线粒体替代疗法的争议。
Fertil Steril. 2015 Feb;103(2):344-6. doi: 10.1016/j.fertnstert.2014.10.028. Epub 2014 Nov 20.