Carow Juliane, Carow John Bennet, Coburn Mark, Kim Bong-Sung, Bücking Benjamin, Bliemel Christopher, Bollheimer Leo Cornelius, Werner Cornelius Johannes, Bach Jan Philipp, Knobe Matthias
RWTH Aachen University Hospital, Department of Orthopaedic Trauma, Aachen, Germany.
RWTH Aachen University Hospital, Department of Anaesthesiology, Aachen, Germany.
Int Orthop. 2017 Nov;41(11):2371-2380. doi: 10.1007/s00264-017-3639-3. Epub 2017 Sep 18.
Despite intense research and innovations in peri-operative management, a high mortality rate and frequent systemic complications in trochanteric femoral fractures persist. The aim of the present study was to identify predictive factors for mortality and cardio-respiratory complications after different treatment methods in a ten year period at a level I trauma centre.
Retrospectively, all patients above 60 years of age with trochanteric femoral fracture between January 2000 and May 2011 were analyzed at a level I trauma centre. Demographic variables, comorbidities, and data regarding the surgical procedures, including required transfusions and post-operative complications, were evaluated, and the in-hospital mortality was recorded. The grade of osteoporosis was classified radiographically using the Singh index.
The in-hospital mortality rate was 8.2% among 437 patients (male/female ratio = 110/327, mean age = 81 years) with extramedullary open (n = 144), intramedullary (n = 166), and extramedullary minimally invasive (n = 125) procedures. Significant influential factors on in-hospital mortality were identified with binary logistic regression analysis: an age of ≥90 years (P = 0.011), male sex (P = 0.003), a high American Society of Anesthesiologists (ASA) grade (3-5, P = 0.042), and a high osteoporosis grade (Singh index 3-1, P = 0.011). A total of 21.5% of the study population suffered cardio-respiratory complications post-operatively. The specific mortality was 28.7% (P < 0.001), which was influenced by a high ASA grade (3-5, P = 0.002) and a high transfusion rate (P = 0.004). Minimally invasive locked plating was associated with increased cardio-respiratory complications (P = 0.031).
This study identified high patient age, distinctive comorbidities, male sex, and high osteoporosis grade as significant risk factors for increased in-hospital mortality in the treatment of trochanteric femoral fractures. Furthermore, high ASA grade and a liberal transfusion regime led to an increased incidence of cardio-respiratory complications. Patient-specific characteristics, especially osteoporosis grade and pre-existing medical conditions, may assist in the identification of high-risk patients and allow a patient-specific geriatric co-management plan.
尽管围手术期管理方面进行了深入研究和创新,但股骨转子间骨折的高死亡率和频繁的全身并发症仍然存在。本研究的目的是确定在一级创伤中心十年期间不同治疗方法后死亡率和心肺并发症的预测因素。
回顾性分析2000年1月至2011年5月在一级创伤中心的所有60岁以上股骨转子间骨折患者。评估人口统计学变量、合并症以及包括所需输血和术后并发症在内的手术相关数据,并记录住院死亡率。使用辛格指数通过X线片对骨质疏松程度进行分类。
437例患者(男/女比例 = 110/327,平均年龄 = 81岁)接受了髓外开放(n = 144)、髓内(n = 166)和髓外微创(n = 125)手术,住院死亡率为8.2%。通过二元逻辑回归分析确定了对住院死亡率有显著影响的因素:年龄≥90岁(P = 0.011)、男性(P = 0.003)、美国麻醉医师协会(ASA)高分级(3 - 5级,P = 0.042)以及骨质疏松高分级(辛格指数3 - 1级,P = 0.011)。共有21.5%的研究人群术后出现心肺并发症。特定死亡率为28.7%(P < 0.001),受ASA高分级(3 - 5级,P = 0.002)和高输血率(P = 0.004)影响。微创锁定钢板固定与心肺并发症增加相关(P = 0.031)。
本研究确定高龄、独特的合并症、男性以及骨质疏松高分级是股骨转子间骨折治疗中住院死亡率增加的重要危险因素。此外,高ASA分级和宽松的输血方案导致心肺并发症发生率增加。患者的特定特征,尤其是骨质疏松分级和既往病史,可能有助于识别高危患者,并制定针对患者的老年综合管理计划。