Litwińska B, Sadowski W, Kańtoch M
Department of Virology, National Institute of Hygiene, Warsaw, Poland.
Acta Virol. 1987 Aug;31(4):298-306.
The effect of cyclophosphamide (CY) and hydrocortisone (HY) on the susceptibility of mice to intracerebral and intraperitoneal infection with herpes simplex virus type 1 (HSV-1) was investigated. The mean survival time, the survival ration, the localization of HSV-1 antigen in brain, spleen and liver as well as immunity after immunization with inactivated virus were determined. In the case of primary infection, an increased susceptibility to HSV-1 was observed after administration of the immunosuppressive drug. Immunization increased the resistance of mice to virus challenge, but no such effect was observed when the virus challenge, but no such effect was observed when or HY. The influence of CY and HY on the immunization process itself was divergent: when HY was given at the time of immunization, the resistance to virus challenge was abolished. On the other hand, CY given simultaneously with inactivated HSV-1 did not depress the immunization effect.
研究了环磷酰胺（CY）和氢化可的松（HY）对小鼠感染1型单纯疱疹病毒（HSV-1）脑内和腹腔内易感性的影响。测定了平均存活时间、存活率、HSV-1抗原在脑、脾和肝中的定位以及用灭活病毒免疫后的免疫力。在原发性感染的情况下，给予免疫抑制药物后观察到对HSV-1的易感性增加。免疫增强了小鼠对病毒攻击的抵抗力，但在病毒攻击时未观察到这种效果，或未观察到HY的这种效果。CY和HY对免疫过程本身的影响是不同的：在免疫时给予HY，对病毒攻击的抵抗力被消除。另一方面，与灭活的HSV-1同时给予CY不会降低免疫效果。
