对感染不同毒力的人类流感病毒株的豚鼠眼睛进行的临床和形态学研究。
Clinical and morphologic studies on the guinea pig eye infected with human influenza virus strains of different virulence.
作者信息
Rozina E E, Khudaverdyan O E
机构信息
Moscow Research Institute of Viral Preparations, U.S.S.R. Ministry of Health, Moscow.
出版信息
Acta Virol. 1987 Aug;31(4):340-5.
PMID:2892383
Abstract
Human influenza virus serotypes H3N2 and H2N2 caused iridocyclitis and uveitis when inoculated at does of 10(6) 6.5 EID50 into the guinea pig eye anterior chamber. Virulent influenza virus strains and their attenuated variants prepared by passaging in chick embryos (CE) have been compared in this model. These studies showed that virulent viruses cause more severe damage in the eyes than the attenuated strains.
摘要
当以10(6) 6.5个鸡胚感染剂量（EID50）接种到豚鼠眼前房时，人类流感病毒血清型H3N2和H2N2会引起虹膜睫状体炎和葡萄膜炎。在该模型中，对强毒流感病毒株及其通过在鸡胚（CE）中传代制备的减毒株进行了比较。这些研究表明，强毒病毒对眼睛造成的损害比减毒株更严重。
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