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A randomized, double-blind trial comparing continuous thoracic epidural bupivacaine with and without opioid in contrast to a continuous paravertebral infusion of bupivacaine for post-thoracotomy pain.一项比较连续胸椎硬膜外布比卡因联合或不联合阿片类药物与连续椎旁布比卡因输注用于开胸术后疼痛的随机、双盲试验。
J Cardiothorac Vasc Anesth. 2012 Feb;26(1):83-9. doi: 10.1053/j.jvca.2011.09.003. Epub 2011 Nov 17.
2
Risks and benefits of thoracic epidural anaesthesia.胸段硬膜外麻醉的风险与获益。
Br J Anaesth. 2011 Dec;107(6):859-68. doi: 10.1093/bja/aer339. Epub 2011 Nov 4.
3
Intra-operative paravertebral block for postoperative analgesia in thoracotomy patients: a randomized, double-blind, placebo-controlled study.术中椎旁阻滞用于开胸术后镇痛:一项随机、双盲、安慰剂对照研究。
Eur J Cardiothorac Surg. 2011 Oct;40(4):902-6. doi: 10.1016/j.ejcts.2011.01.067. Epub 2011 Mar 5.
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Sedation assessment using the Ramsay scale.使用拉姆齐量表进行镇静评估。
Emerg Nurse. 2010 Jun;18(3):18-20. doi: 10.7748/en2010.06.18.3.18.c7825.
5
Efficacy and safety of different techniques of paravertebral block for analgesia after thoracotomy: a systematic review and metaregression.开胸术后不同椎旁阻滞技术用于镇痛的有效性和安全性:一项系统评价和Meta回归分析
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Public Health Rep. 2009 May-Jun;124(3):471-4. doi: 10.1177/003335490912400320.
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A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia.一项对评估开胸术后镇痛区域技术的随机试验的系统评价。
Anesth Analg. 2008 Sep;107(3):1026-40. doi: 10.1213/01.ane.0000333274.63501.ff.
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Preventing and treating pain after thoracic surgery.预防和治疗胸外科手术后的疼痛。
Anesthesiology. 2006 Mar;104(3):594-600. doi: 10.1097/00000542-200603000-00027.
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A comparison of the analgesic efficacy and side-effects of paravertebral vs epidural blockade for thoracotomy--a systematic review and meta-analysis of randomized trials.开胸手术中椎旁阻滞与硬膜外阻滞镇痛效果及副作用的比较——随机试验的系统评价和荟萃分析
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Post-thoracotomy pain after thoracic epidural analgesia: a prospective follow-up study.开胸术后胸段硬膜外镇痛后的疼痛:一项前瞻性随访研究。
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连续胸椎硬膜外阻滞与连续胸椎旁神经阻滞在胸部创伤管理中的比较。

Comparison between continuous thoracic epidural block and continuous thoracic paravertebral block in the management of thoracic trauma.

作者信息

Singh Shalendra, Jacob Mathews, Hasnain S, Krishnakumar Mathangi

机构信息

Classified Specialist (Neuroanaesthesia), AIIMS, New Delhi 110029, India.

Senior Adviser (Anaesthesiology), Command Hospital (Central Command), Lucknow, India.

出版信息

Med J Armed Forces India. 2017 Apr;73(2):146-151. doi: 10.1016/j.mjafi.2016.11.005. Epub 2016 Dec 24.

DOI:10.1016/j.mjafi.2016.11.005
PMID:28924315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5592259/
Abstract

BACKGROUND

Postoperative pain is thought to be the single most important factor leading to ineffective ventilation and impaired secretion clearance after thoracic trauma. Effective pain relief can be provided by thoracic epidural analgesia but may have side effects or contraindications. Paravertebral block is an effective alternative method without the side effects of a thoracic epidural. We did this study to compare efficacy of thoracic epidural and paravertebral block in providing analgesia to thoracic trauma patients.

METHODS

After ethical clearance, 50 patients who had thoracic trauma were randomized into two groups. One was a thoracic epidural group (25), and second was a paravertebral group (25). Both groups received 10 ml of bolus of plain 0.125% bupivacaine and a continuous infusion of 0.25% bupivacaine at the rate of 0.1 ml/kg/h for 24 h. Assessment of pain, hemodynamic parameters, and spirometric measurements of pulmonary function were done before and after procedure. Visual analog scale (VAS) scores were accepted as main outcome of the study and taken for power analysis.

RESULTS

There was significant decrease in postoperative pain in both the groups as measured by VAS score. However, the degree of pain relief between the groups was comparable. There was a significant improvement in pulmonary function tests in both the groups post-procedure. The change in amount of inflammatory markers between both the groups was not significantly different.

CONCLUSION

Paravertebral block for analgesia is comparable to thoracic epidural in thoracic trauma patients and is associated with fewer side effects.

摘要

背景

术后疼痛被认为是导致胸部创伤后通气无效和分泌物清除受损的最重要单一因素。胸段硬膜外镇痛可有效缓解疼痛,但可能有副作用或禁忌证。椎旁阻滞是一种有效的替代方法,且无胸段硬膜外阻滞的副作用。我们进行这项研究以比较胸段硬膜外阻滞和椎旁阻滞对胸部创伤患者的镇痛效果。

方法

经伦理批准后,将50例胸部创伤患者随机分为两组。一组为胸段硬膜外组(25例),另一组为椎旁组(25例)。两组均接受10 ml的0.125%布比卡因原液推注,并以0.1 ml/kg/h的速度持续输注0.25%布比卡因24小时。在操作前后对疼痛、血流动力学参数和肺功能进行肺活量测定评估。视觉模拟量表(VAS)评分被视为研究的主要结果并用于效能分析。

结果

两组患者术后疼痛通过VAS评分测量均显著降低。然而,两组之间的疼痛缓解程度相当。两组患者术后肺功能测试均有显著改善。两组之间炎症标志物数量的变化无显著差异。

结论

在胸部创伤患者中,椎旁阻滞镇痛与胸段硬膜外阻滞效果相当,且副作用较少。