Singh Shalendra, Jacob Mathews, Hasnain S, Krishnakumar Mathangi
Classified Specialist (Neuroanaesthesia), AIIMS, New Delhi 110029, India.
Senior Adviser (Anaesthesiology), Command Hospital (Central Command), Lucknow, India.
Med J Armed Forces India. 2017 Apr;73(2):146-151. doi: 10.1016/j.mjafi.2016.11.005. Epub 2016 Dec 24.
Postoperative pain is thought to be the single most important factor leading to ineffective ventilation and impaired secretion clearance after thoracic trauma. Effective pain relief can be provided by thoracic epidural analgesia but may have side effects or contraindications. Paravertebral block is an effective alternative method without the side effects of a thoracic epidural. We did this study to compare efficacy of thoracic epidural and paravertebral block in providing analgesia to thoracic trauma patients.
After ethical clearance, 50 patients who had thoracic trauma were randomized into two groups. One was a thoracic epidural group (25), and second was a paravertebral group (25). Both groups received 10 ml of bolus of plain 0.125% bupivacaine and a continuous infusion of 0.25% bupivacaine at the rate of 0.1 ml/kg/h for 24 h. Assessment of pain, hemodynamic parameters, and spirometric measurements of pulmonary function were done before and after procedure. Visual analog scale (VAS) scores were accepted as main outcome of the study and taken for power analysis.
There was significant decrease in postoperative pain in both the groups as measured by VAS score. However, the degree of pain relief between the groups was comparable. There was a significant improvement in pulmonary function tests in both the groups post-procedure. The change in amount of inflammatory markers between both the groups was not significantly different.
Paravertebral block for analgesia is comparable to thoracic epidural in thoracic trauma patients and is associated with fewer side effects.
术后疼痛被认为是导致胸部创伤后通气无效和分泌物清除受损的最重要单一因素。胸段硬膜外镇痛可有效缓解疼痛,但可能有副作用或禁忌证。椎旁阻滞是一种有效的替代方法,且无胸段硬膜外阻滞的副作用。我们进行这项研究以比较胸段硬膜外阻滞和椎旁阻滞对胸部创伤患者的镇痛效果。
经伦理批准后,将50例胸部创伤患者随机分为两组。一组为胸段硬膜外组(25例),另一组为椎旁组(25例)。两组均接受10 ml的0.125%布比卡因原液推注,并以0.1 ml/kg/h的速度持续输注0.25%布比卡因24小时。在操作前后对疼痛、血流动力学参数和肺功能进行肺活量测定评估。视觉模拟量表(VAS)评分被视为研究的主要结果并用于效能分析。
两组患者术后疼痛通过VAS评分测量均显著降低。然而,两组之间的疼痛缓解程度相当。两组患者术后肺功能测试均有显著改善。两组之间炎症标志物数量的变化无显著差异。
在胸部创伤患者中,椎旁阻滞镇痛与胸段硬膜外阻滞效果相当,且副作用较少。