Behm R, Bathelt S, Gerber B, Nollau K, Pfeiffer C
Institute of Physiology, Wilhelm-Pieck University Rostock, DDR.
Biomed Biochim Acta. 1987;46(7):611-7.
The effect of almitrine on salt appetite, water intake, and renal excretory function was investigated in conscious adult spontaneously hypertensive rats (SHR) of both sexes. The animals were kept singly in metabolic cages and given free access to food, water and 2.5% NaCl-solution. Oral administration of almitrine (0.4 mg/kg) for five days evoked an effective long-lasting suppression of voluntary salt intake and a temporary decrease of water intake. The pattern of renal electrolyte excretion was determined by the pattern of intake. The present results support the assumption that the activity of the peripheral arterial chemoreceptors plays an essential role in the maintenance of voluntary salt intake in SHR.
研究了烯丙哌三嗪对成年自发性高血压大鼠（SHR）（雌雄均有）的盐食欲、水摄入量及肾脏排泄功能的影响。将动物单独饲养在代谢笼中，可自由获取食物、水和2.5%的氯化钠溶液。口服烯丙哌三嗪（0.4毫克/千克），持续五天，可有效长期抑制自发性盐摄入量，并使水摄入量暂时减少。肾脏电解质排泄模式由摄入模式决定。目前的结果支持以下假设：外周动脉化学感受器的活动在SHR自发性盐摄入的维持中起重要作用。
