Behm R, Franz U, Sitarek U
Institute of Physiology, Wilhelm-Pieck University, GDR, Rostock.
Biomed Biochim Acta. 1987;46(12):987-91.
The effect of normobaric hyperoxia on voluntary salt intake was investigated in conscious male SHR (n = 16). The animals were housed individually in metabolic cages and given free access to food, water and 2.5% NaCl-solution. The exposure of the rats to 40% oxygen in nitrogen for four days resulted in a significant enhancement of the salt intake. The present experiment further clarifies the relationship between chemoreceptor activity and salt intake. Hypobaric hypoxia as well as the pharmacological substance almitrine, both stimuli of the carotid bodies, decrease the voluntary salt intake in SHR significantly, whereas hyperoxia, characterized by lowering of the chemoreceptor activity, increases the salt intake. Our studies support the hypothesis that chemoreceptor activity has a modulating influence on salt appetite in SHR.
在清醒的雄性自发性高血压大鼠（SHR，n = 16）中研究了常压高氧对自愿性盐摄入的影响。将动物单独饲养在代谢笼中，可自由获取食物、水和2.5%的氯化钠溶液。将大鼠置于含40%氧气的氮气环境中4天，导致盐摄入量显著增加。本实验进一步阐明了化学感受器活动与盐摄入之间的关系。低压缺氧以及药理物质烯丙哌三嗪，这两种颈动脉体刺激物，均显著降低SHR的自愿性盐摄入量，而以化学感受器活动降低为特征的高氧则增加盐摄入量。我们的研究支持以下假设：化学感受器活动对SHR的盐食欲具有调节作用。
