Roberts S E, Brown T H, Thorne K, Lyons R A, Akbari A, Napier D J, Brown J L, Williams J G
Swansea University Medical School, Swansea University, Swansea, UK.
Farr Institute of Health Informatics Research, Swansea University, Swansea, UK.
Br J Surg. 2017 Nov;104(12):1723-1734. doi: 10.1002/bjs.10608. Epub 2017 Sep 19.
Little has been reported on mortality following admissions at weekends for many gastrointestinal (GI) disorders. The aim was to establish whether GI disorders are susceptible to increased mortality following unscheduled admission on weekends compared with weekdays.
Record linkage was undertaken of national administrative inpatient and mortality data for people in England and Wales who were hospitalized as an emergency for one of 19 major GI disorders.
The study included 2 254 701 people in England and 155 464 in Wales. For 11 general surgical and medical GI disorders there were little, or no, significant weekend effects on mortality at 30 days in either country. There were large consistent weekend effects in both countries for severe liver disease (England: 26·2 (95 per cent c.i. 21·1 to 31·6) per cent; Wales: 32·0 (12·4 to 55·1 per cent) and GI cancer (England: 21·8 (19·1 to 24·5) per cent; Wales: 25·0 (15·0 to 35·9) per cent), which were lower in patients managed by surgeons. Admission rates were lower at weekends than on weekdays, most strongly for severe liver disease (by 43·3 per cent in England and 51·4 per cent in Wales) and GI cancer (by 44·6 and 52·8 per cent respectively). Both mortality and the weekend mortality effect for GI cancer were lower for patients managed by surgeons.
There is little, or no, evidence of a weekend mortality effect for most major general surgical or medical GI disorders, but large weekend effects for GI cancer and severe liver disease. Lower admission rates at weekends indicate more severe cases. The findings for severe liver disease may suggest a lack of specialist hepatological resources. For cancers, reduced availability of end-of-life care in the community at weekends may be the cause.
关于许多胃肠道疾病患者在周末入院后的死亡率,此前报道较少。本研究旨在确定与工作日相比,胃肠道疾病患者在周末非计划入院后死亡率是否更高。
对英格兰和威尔士因19种主要胃肠道疾病之一而急诊住院的患者的国家行政住院和死亡数据进行记录链接。
该研究纳入了2254701名英格兰患者和155464名威尔士患者。对于11种普通外科和内科胃肠道疾病,在这两个国家,30天死亡率几乎没有或没有显著的周末效应。在这两个国家,严重肝病(英格兰:26.2%(95%置信区间21.1至31.6);威尔士:32.0%(12.4至55.1%))和胃肠道癌症(英格兰:21.8%(19.1至24.5);威尔士:25.0%(15.0至35.9%))存在一致的较大周末效应,外科医生治疗的患者中这些效应较低。周末的入院率低于工作日,严重肝病(英格兰降低43.3%,威尔士降低51.4%)和胃肠道癌症(分别降低44.6%和52.8%)最为明显。外科医生治疗的胃肠道癌症患者的死亡率和周末死亡率效应均较低。
对于大多数主要的普通外科或内科胃肠道疾病,几乎没有或没有证据表明存在周末死亡率效应,但胃肠道癌症和严重肝病存在较大的周末效应。周末较低的入院率表明病情更严重。严重肝病的研究结果可能表明缺乏专科肝病资源。对于癌症,周末社区临终关怀服务的可及性降低可能是原因。