Cerk Ines Katrin, Wechselberger Lisa, Oberer Monika
Institute of Molecular Biosciences, BioTechMed Graz, University of Graz, A-8010 Graz, Austria.
Curr Protein Pept Sci. 2018;19(2):221-233. doi: 10.2174/1389203718666170918160110.
Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the FA mobilization process also have fundamental regulatory functions affecting cell signaling, gene expression, metabolism, cell growth, cell death, and lipotoxicity. Regulation of ATGL is therefore vital for maintaining a defined balance between lipid storage and mobilization. This review addresses the regulation of ATGL activity at the post-translational level with special emphasis on protein-mediated interaction at the site of hydrolytic action, namely to the lipid droplet.
脂肪甘油三酯脂肪酶（ATGL）是细胞内脂肪分解过程中从甘油三酯（TG）储存中释放脂肪酸（FAs）的关键酶，所产生的脂肪酸用于能量生成。越来越多的证据表明，在脂肪酸动员过程中脂解分解的产物和中间产物也具有影响细胞信号传导、基因表达、代谢、细胞生长、细胞死亡和脂毒性的基本调节功能。因此，ATGL的调节对于维持脂质储存和动员之间的特定平衡至关重要。本综述探讨了翻译后水平上ATGL活性的调节，特别强调了水解作用部位即脂滴处蛋白质介导的相互作用。
