Asero R, Origgi L, Crespi S, Bertetti E, D'Agostino P, Riboldi P
Istituto di Medicina Interna, Università degli Studi di Milano, Italia.
Clin Exp Rheumatol. 1987 Jul-Sep;5(3):241-6.
In a clinical and serological follow-up study on a large series of subjects with different connective tissue disorders, anti-PCNA/cyclin autoantibodies were found in about 3% of patients with SLE. Positive subjects showed a higher incidence of diffuse proliferative glomerulonephritis and hematological disorders than the general SLE population. A highly significant serological association between PCNA and SL/Ki autoantibodies (p less than 0.001) has been observed. Persistence or disappearance of serum PCNA antibodies were independent of any clinical and serological feature or the therapeutic regimen employed.
在一项针对大量患有不同结缔组织疾病的受试者的临床和血清学随访研究中，约3%的系统性红斑狼疮（SLE）患者体内发现了抗增殖细胞核抗原/细胞周期蛋白自身抗体。阳性受试者弥漫性增殖性肾小球肾炎和血液系统疾病的发生率高于SLE总体人群。已观察到增殖细胞核抗原（PCNA）与SL/Ki自身抗体之间存在高度显著的血清学关联（p<0.001）。血清PCNA抗体的持续存在或消失与任何临床和血清学特征或所采用的治疗方案无关。
