Shen Jie, Hodges Tiffany R, Song Renduo, Gong Ye, Calin George A, Heimberger Amy B, Zhao Hua
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mol Carcinog. 2018 Jan;57(1):137-141. doi: 10.1002/mc.22739. Epub 2017 Oct 10.
Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers. However, their significance in predicting outcomes in glioblastoma patients is unclear. We measured the levels of six known oncogenic lncRNAs-CRNDE, GAS5, H19, HOTAIR, MALAT1, and TUG1 in serum samples from 106 patients with primary glioblastoma and analyzed their association with outcomes. High levels of HOTAIR were associated with decreased probability of 2-year overall survival (adjusted hazard ratio [HR] = 2.04; 95% confidence interval [CI] = 1.08-9.76), and disease-free survival (adjusted HR = 1.82; 95% CI = 1.04-6.17). High levels of GAS5 were associated with increased probability of 2-year overall survival (adjusted HR = 0.44; 95% CI = 0.18-0.99), and disease-free survival (adjusted HR = 0.46; 95% CI = 0.16-0.98). HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma.
循环长链非编码RNA（lncRNAs）是一类新型的癌症生物标志物。然而，它们在预测胶质母细胞瘤患者预后方面的意义尚不清楚。我们检测了106例原发性胶质母细胞瘤患者血清样本中六种已知的致癌lncRNA——CRNDE、GAS5、H19、HOTAIR、MALAT1和TUG1的水平，并分析了它们与预后的相关性。HOTAIR水平高与2年总生存率降低（调整后风险比[HR]=2.04；95%置信区间[CI]=1.08-9.76）及无病生存率降低（调整后HR=1.82；95%CI=1.04-6.17）相关。GAS5水平高与2年总生存率增加（调整后HR=0.44；95%CI=0.18-0.99）及无病生存率增加（调整后HR=0.46；95%CI=0.16-0.98）相关。HOTAIR和GAS5水平可作为胶质母细胞瘤患者生存和疾病进展的相互预后预测指标。
