Federico Alessandro, Dallio Marcello, DI Sarno Rosa, Giorgio Valentina, Miele Luca
Department of Clinical and Experimental Medicine, University of Campania "L. Vanvitelli", Naples, Italy -
Department of Clinical and Experimental Medicine, University of Campania "L. Vanvitelli", Naples, Italy.
Minerva Gastroenterol Dietol. 2017 Dec;63(4):337-344. doi: 10.23736/S1121-421X.17.02376-5.
Obesity, diabetes and metabolic disorders represent hugely significant problems concerning the health in Western countries and the study of gut microbiota in metabolic pathologies is part of this framework. Diet effects on intestinal microbial composition and its role in pathogenetic mechanisms responsible for both obesity and systemic, hepatic and adipose tissue inflammation, represent at the moment one of this mostpromising topic in gastroenterology research. Gut health safety is essential, but it needs to be further explored in order to understand and interrupt the pathogenetic mechanisms, which support a large number of diseases. The aim of this review is to describe what are the modifications of gut microbial composition that occur in metabolic disorders and the role of gut microbiota in the pathogenesis of several diseases such as obesity, metabolic syndrome and type II diabetes mellitus, showing how gut microbiota and adipose tissue, liver and brain, together with intestinal permeability increase, carry out an interconnection systemthat plays a pivotal role in the field.
肥胖、糖尿病和代谢紊乱是西方国家极为重要的健康问题，而肠道微生物群在代谢性疾病中的研究是这一框架的一部分。饮食对肠道微生物组成的影响及其在肥胖以及全身、肝脏和脂肪组织炎症的致病机制中的作用，目前是胃肠病学研究中最有前景的课题之一。肠道健康安全至关重要，但需要进一步探索以了解和阻断支持大量疾病的致病机制。本综述的目的是描述代谢紊乱中肠道微生物组成的变化，以及肠道微生物群在肥胖、代谢综合征和II型糖尿病等几种疾病发病机制中的作用，展示肠道微生物群与脂肪组织、肝脏和大脑如何与肠道通透性增加一起形成一个在该领域起关键作用的相互连接系统。
