Department of Endocrinology & Metabolism and West China Biomedical Big Data Center, West China Hospital, Sichuan University/West China School of Nursing, Chengdu 610041, China.
Med-X Center for Informatics, Sichuan University, Chengdu 610041, China.
Nutrients. 2023 Jul 23;15(14):3255. doi: 10.3390/nu15143255.
Obesity is a serious public health problem. According to statistics, there are millions of obese people worldwide. Research studies have discovered a complex and intricate relationship between the gut microbiota and obesity. Probing and summarizing the relationship between intestinal microbes and obesity has important guiding significance for the accurate control of the research direction and expanding the choice of obesity treatment methods. We used bibliometric analysis to analyze the published literature with the intention to reveal the research hotspots and development trends on the effects of intestinal microbes on obesity from a visualization perspective, both qualitatively and quantitatively. The results showed that current research is focusing on related mechanisms of the effects of intestinal microbes on obesity and therapeutic methods for obesity. Several noteworthy hotspots within this field have garnered considerable attention and are expected to remain the focal points of future research. Of particular interest are the mechanisms by which intestinal microbes potentially regulate obesity through metabolite interactions, as well as the role of microbiomes as metabolic markers of obesity. These findings strongly suggest that gut microbes continue to be a key target in the quest for effective obesity treatments. Co-operation and communication between countries and institutions should be strengthened to promote development in this field to benefit more patients with obesity.
肥胖是一个严重的公共卫生问题。据统计，全球有数百万人肥胖。研究发现，肠道微生物群与肥胖之间存在复杂的关系。探究肠道微生物与肥胖之间的关系，对准确把握研究方向、拓展肥胖治疗方法的选择具有重要的指导意义。我们采用文献计量学分析方法，对已发表的文献进行分析，旨在从定性和定量两个方面，通过可视化的方式揭示肠道微生物对肥胖影响的研究热点和发展趋势。结果表明，目前的研究主要集中在肠道微生物对肥胖影响的相关机制和肥胖的治疗方法上。该领域的几个热点受到了相当多的关注，预计将成为未来研究的焦点。特别值得关注的是肠道微生物通过代谢物相互作用潜在调节肥胖的机制，以及微生物组作为肥胖代谢标志物的作用。这些发现强烈表明，肠道微生物仍然是寻找有效肥胖治疗方法的关键目标。应该加强国家和机构之间的合作与交流，促进该领域的发展，使更多的肥胖患者受益。
