[过去25年阿根廷代谢综合征的患病率：人群观察性研究的系统评价]
[Prevalence of metabolic syndrome in Argentina in the last 25 years: systematic review of population observational studies].
作者信息
Diaz A, Espeche W, March C, Flores R, Parodi R, Genesio M A, Sabio R, Poppe S
机构信息
Grupo de Trabajo en Epidemiología, Sociedad Argentina de Hipertensión Arterial, Ciudad Autónoma de Buenos Aires, Argentina; Instituto de Investigación en Ciencias de la Salud, CONICET, Ciudad de Tandil, Argentina.
Grupo de Trabajo en Epidemiología, Sociedad Argentina de Hipertensión Arterial, Ciudad Autónoma de Buenos Aires, Argentina.
出版信息
Hipertens Riesgo Vasc. 2018 Apr-Jun;35(2):64-69. doi: 10.1016/j.hipert.2017.08.003. Epub 2017 Sep 18.
INTRODUCTION AND AIM
Metabolic syndrome (MS) comprises a set of risk factors for cardiovascular disease and diabetes. Argentina has numerous epidemiological studies on MS, however, there has been no systematic analysis of the prevalence of MS in our population. To estimate the prevalence of MS in the Argentine Republic, a systematic review of observational studies published during the period 1988-2014 was carried out.
SEARCH STRATEGY
A bibliographic search was conducted in the MEDLINE (National Library of Medicine), SciELO (Scientific Electronic Library Online) and LILACS (Latin American and Caribbean Health Sciences Literature) databases on studies conducted in Argentina between January 1989 and December 2014. The following search terms were combined in English, Spanish and Portuguese: 'metabolic syndrome', 'insulin resistance', 'dysmetabolic syndrome', 'prevalence', 'epidemiology', and 'Argentina'.
SELECTION OF STUDIES
Epidemiological studies based on the adult population of Argentina with specific report of the prevalence of MS (according to the WHO, ATP III or IDF criteria) were included in the analysis.
SYNTHESIS RESULTS
In the initial bibliographic search, 400 publications were identified. In the second phase of search, 296 titles and abstracts were excluded. In the third phase, the full text of 104 studies was analyzed. Finally, 6 publications were included in the analysis that reported the prevalence of MS in a total of 10,191 subjects (39.6% male). The average age of the population was 45.2 years. The prevalence of MS (random effects model) was 27.5% (95% CI: 21.3%-34.1%). The prevalence of MS was higher in men than in women (29.4% vs. 27.4%, respectively, P=.02). In order of frequency, the most common components of MS were dyslipidaemia (38.3%), hypertension (33.4%), obesity (32.1%) and diabetes (7.5%).
CONCLUSIONS
Our data show that the prevalence of MS is high, which represents a very important public health problem in Argentina.
引言与目的
代谢综合征（MS）包含一系列心血管疾病和糖尿病的危险因素。阿根廷有众多关于MS的流行病学研究，然而，尚未对我国人群中MS的患病率进行系统分析。为估算阿根廷共和国MS的患病率，我们对1988年至2014年期间发表的观察性研究进行了系统综述。
检索策略
在MEDLINE（美国国立医学图书馆）、SciELO（科学电子图书馆在线）和LILACS（拉丁美洲和加勒比卫生科学文献）数据库中进行文献检索，检索1989年1月至2014年12月在阿根廷开展的研究。以下检索词用英文、西班牙文和葡萄牙文组合：“代谢综合征”、“胰岛素抵抗”、“代谢紊乱综合征”、“患病率”、“流行病学”以及“阿根廷”。
研究选择
分析纳入基于阿根廷成年人群且有MS患病率具体报告（根据世界卫生组织、ATP III或国际糖尿病联盟标准）的流行病学研究。
综合结果
在最初的文献检索中，共识别出400篇出版物。在第二阶段检索中，排除了296篇标题和摘要。在第三阶段，分析了104项研究的全文。最后，纳入6篇报告了MS患病率的分析，这些研究共涉及10191名受试者（男性占39.6%）。人群的平均年龄为45.2岁。MS的患病率（随机效应模型）为27.5%（95%置信区间：21.3%-34.1%）。MS在男性中的患病率高于女性（分别为29.4%和27.4%，P = 0.02）。按出现频率排序，MS最常见的组成部分依次为血脂异常（38.3%）、高血压（33.4%）、肥胖（32.1%）和糖尿病（7.5%）。
结论
我们的数据表明，MS的患病率很高，这在阿根廷是一个非常重要的公共卫生问题。
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