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断奶过渡期商品仔猪肠道微生物群的成熟发育

The Maturing Development of Gut Microbiota in Commercial Piglets during the Weaning Transition.

作者信息

Chen Limei, Xu Yuesong, Chen Xiaoyu, Fang Chao, Zhao Liping, Chen Feng

机构信息

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong UniversityShanghai, China.

Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong UniversityShanghai, China.

出版信息

Front Microbiol. 2017 Sep 4;8:1688. doi: 10.3389/fmicb.2017.01688. eCollection 2017.

DOI:10.3389/fmicb.2017.01688
PMID:28928724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5591375/
Abstract

Early weaned piglets are vulnerable to diarrhea because of weaning stress and immaturity of intestinal tract. Compelling evidence suggests that gut microbiota is vital to host health. However, it is not well understood on the composition and succession of piglet gut microbiota during the weaning transition. In our two trials, total 17 commercial piglets were studied in a pig farm in Jiangxi Province, China. Fresh feces were collected for four times (10 days before weaned, weaned day, 10 days after weaned, 21 days after weaned) by rectal massage. Fecal bacterial composition was assessed by 16S rRNA gene V3-V4 regions sequencing by Illumina Miseq platform. The results showed that the gut microbiota of piglets shifted quickly after weaned and reached relatively stable level in 10 days after weaned. The alpha diversity increased significantly with the age of piglets. The microbiota of suckling piglets was mainly represented by , and . This pattern contrasted with that of XIVa, and , which were major representative genera after weaned. In summary, we delineated the development of piglet gut microbiota during the weaning transition. This study helps us understand the maturing development of gut microbiota in commercial piglets.

摘要

早期断奶仔猪由于断奶应激和肠道不成熟，易患腹泻。有力证据表明，肠道微生物群对宿主健康至关重要。然而，关于断奶过渡期仔猪肠道微生物群的组成和演替，目前尚不清楚。在我们的两项试验中，在中国江西省的一个猪场对总共17头商品仔猪进行了研究。通过直肠按摩，在四个时间点（断奶前10天、断奶日、断奶后10天、断奶后21天）采集新鲜粪便。通过Illumina Miseq平台对粪便细菌组成进行16S rRNA基因V3-V4区域测序评估。结果表明，仔猪断奶后肠道微生物群迅速变化，并在断奶后10天达到相对稳定水平。α多样性随仔猪年龄显著增加。哺乳仔猪的微生物群主要由 、 和 代表。这种模式与断奶后主要代表性菌属XIVa、 和 形成对比。总之，我们描绘了断奶过渡期仔猪肠道微生物群的发育情况。这项研究有助于我们了解商品仔猪肠道微生物群的成熟发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/b9bf7dea13e4/fmicb-08-01688-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/680f388914f0/fmicb-08-01688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/8abb279f34cb/fmicb-08-01688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/740d932ef0bb/fmicb-08-01688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/459658ce197e/fmicb-08-01688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/0962aff38ab8/fmicb-08-01688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/dc0317e424c5/fmicb-08-01688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/b9bf7dea13e4/fmicb-08-01688-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/680f388914f0/fmicb-08-01688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/8abb279f34cb/fmicb-08-01688-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/740d932ef0bb/fmicb-08-01688-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/459658ce197e/fmicb-08-01688-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/0962aff38ab8/fmicb-08-01688-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/dc0317e424c5/fmicb-08-01688-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38c9/5591375/b9bf7dea13e4/fmicb-08-01688-g007.jpg

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[6]
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Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.

Gastroenterology. 2017-3

[2]
Gradual Changes of Gut Microbiota in Weaned Miniature Piglets.

Front Microbiol. 2016-11-2

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