Lo Sicco Claudia, Tasso Roberta
Department of Experimental Medicine, University of Genoa, Genoa, Italy.
Ospedale Policlinico San Martino, Istituto di Ricovero e Cura a Carattere Scientifico per l'Oncologia, Genoa, Italy.
Front Bioeng Biotechnol. 2017 Sep 4;5:52. doi: 10.3389/fbioe.2017.00052. eCollection 2017.
Although autologous tissue transplantation represents a valid approach for bone repair, it has encountered crucial barriers in therapeutic translation, not least the invasive process necessary for stem cell isolation. In recent years, the scientific community has made significant strides for identifying new treatment options, and great emphasis has been placed on the tight interaction between skeletal and immune system in modulating the outcome of bone repair. Within the context of specific injury environmental cues, the cross talk among inflammatory cells and tissue resident and/or circulating progenitor cells is crucial to finely coordinate repair and remodeling processes. The appropriate modulation of the inflammatory response can now be considered a new trend in the field of regenerative medicine, as it raises the attracting possibility to enhance endogenous progenitor cell functions, finally leading to tissue repair. Therefore, new treatment options have been developed considering the wide spectrum of bone-inflammation interplay, considering in particular the cell intrinsic cues responsible for the modulation of the injured environment. In this review, we will provide a panoramic overview focusing on novel findings developed to uphold endogenous bone repair.
尽管自体组织移植是骨修复的一种有效方法，但它在治疗转化过程中遇到了关键障碍，尤其是干细胞分离所需的侵入性过程。近年来，科学界在确定新的治疗选择方面取得了重大进展，并且高度重视骨骼与免疫系统在调节骨修复结果中的紧密相互作用。在特定损伤环境线索的背景下，炎症细胞与组织驻留和/或循环祖细胞之间的相互作用对于精细协调修复和重塑过程至关重要。现在，适当调节炎症反应可被视为再生医学领域的一个新趋势，因为它带来了增强内源性祖细胞功能的诱人可能性，最终导致组织修复。因此，考虑到骨与炎症相互作用的广泛范围，特别是考虑到负责调节损伤环境的细胞内在线索，已经开发了新的治疗选择。在这篇综述中，我们将提供一个全景概述，重点关注为支持内源性骨修复而取得的新发现。
