Xin Hai, Tomaskovic-Crook Eva, Al Maruf D S Abdullah, Cheng Kai, Wykes James, Manzie Timothy G H, Wise Steven G, Crook Jeremy M, Clark Jonathan R
Integrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown, NSW 2050, Australia.
Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.
Gels. 2023 Sep 21;9(9):768. doi: 10.3390/gels9090768.
The periosteum is a thin layer of connective tissue covering bone. It is an essential component for bone development and fracture healing. There has been considerable research exploring the application of the periosteum in bone regeneration since the 19th century. An increasing number of studies are focusing on periosteal progenitor cells found within the periosteum and the use of hydrogels as scaffold materials for periosteum engineering and guided bone development. Here, we provide an overview of the research investigating the use of the periosteum for bone repair, with consideration given to the anatomy and function of the periosteum, the importance of the cambium layer, the culture of periosteal progenitor cells, periosteum-induced ossification, periosteal perfusion, periosteum engineering, scaffold vascularization, and hydrogel-based synthetic periostea.
骨膜是覆盖在骨表面的一层薄结缔组织。它是骨骼发育和骨折愈合的重要组成部分。自19世纪以来，已有大量研究探索骨膜在骨再生中的应用。越来越多的研究聚焦于骨膜内发现的骨膜祖细胞，以及水凝胶作为骨膜工程和引导骨发育的支架材料的应用。在此，我们概述了有关利用骨膜进行骨修复的研究，同时考虑了骨膜的解剖结构和功能、生发层的重要性、骨膜祖细胞的培养、骨膜诱导成骨、骨膜灌注、骨膜工程、支架血管化以及基于水凝胶的合成骨膜。
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