Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.
Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, 4000, Roskilde, Denmark.
Mol Neurobiol. 2018 Jun;55(6):5353-5361. doi: 10.1007/s12035-017-0760-7. Epub 2017 Sep 19.
The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.
Müller 细胞是视网膜中主要的神经胶质细胞。近几十年来，人们逐渐认识到 Müller 细胞对视网膜神经元内环境的稳定具有比之前预想更为深远的影响。由于 Müller 细胞独特的定位，跨越整个视网膜，位于血管和神经元之间，Müller 细胞负责为周围神经元提供功能和代谢支持。由于视网膜对能量的巨大需求，Müller 细胞消耗和处理大量的葡萄糖。本综述从细胞水平上阐述了 Müller 细胞与视网膜内层神经元之间的共生关系，强调了 Müller 细胞内能量代谢对于视网膜神经元存活的重要作用。
