Wang Xiaogang, Dubois Raphael, Young Caitlyn, Lien Eric J, Adams James D
Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90899-9121, USA.
Medicines (Basel). 2016 Jul 7;3(3):17. doi: 10.3390/medicines3030017.
This study examined the chemistry and safety of , also called toyon or California holly, which is a traditional California Indian food and treatment for Alzheimer's disease. Plant extracts were examined by HPLC/MS, NMR and other techniques to identify compounds. Volunteers were recruited to examine the acute safety of the plant medicine using a standard short-term memory test. The plant was found to contain icariside E4, dihydroxyoleanenoic acid, maslinic acid, betulin, trihydroxyoxo-seco-ursdienoic acid, catechin, vicenin-2, farrerol, kaempferide and tetrahydroxyoleanenoic acid. These compounds are anti-inflammatory agents that may protect the blood-brain barrier and prevent inflammatory cell infiltration into the brain. The dried berries were ingested by six volunteers to demonstrate the safety of the medicine. The plant medicine was found to contain several compounds that may be of interest in the treatment of Alzheimer's disease. The plant medicine was found to be safe.
本研究检测了也被称为柳叶石楠或加州冬青的[植物名称未给出]的化学性质和安全性，它是加利福尼亚印第安人的传统食物，也是治疗阿尔茨海默病的药物。通过高效液相色谱/质谱联用仪（HPLC/MS）、核磁共振（NMR）及其他技术对植物提取物进行检测以鉴定化合物。招募志愿者，通过标准短期记忆测试来检测这种植物药的急性安全性。发现该植物含有淫羊藿次苷E4、二羟基齐墩果酸、山楂酸、桦木醇、三羟基氧代-裂环-乌苏二烯酸、儿茶素、异荭草苷、杜鹃素、山柰酚苷和四羟基齐墩果酸。这些化合物是抗炎剂，可能保护血脑屏障并防止炎性细胞浸润入脑。六名志愿者食用了干燥的浆果以证明该药的安全性。发现这种植物药含有几种可能对治疗阿尔茨海默病有意义的化合物。还发现这种植物药是安全的。
